Table 2

Annual changes in pulmonary function test (PFT) results and composite and component CT scores in children and adults

	Children		Adults		Difference between adults and children
	Change (SE)	p value	Change (SE)	p value	p value
FVC, forced vital capacity; FEV₁, forced expiratory volume in 1 second; MEF₂₅, MEF₅₀, mid expiratory flow at 25% and 50% of vital capacity; RV, residual volume; TLC, total lung capacity; AWT, airway wall thickening.
Data were obtained using repeated measurement analysis of variance (RMANOVA). Lung structure or function = slope × age + intercept. MEF₅₀ and MEF₂₅ (% predicted) were ¹⁰log transformed. Being rare, central mucous plugging and bullae or cysts were excluded from the analysis. Composite score adapted from Brody et al.¹³
Function
FVC (Z score)	−0.0006 (0.031)	0.98	0.0051 (0.032)	0.88	0.89
FEV₁ (Z score)	−0.0734 (0.029)	0.03	−0.0397 (0.031)	0.23	0.47
RV (Z score)	0.0105 (0.035)	0.77	0.1025 (0.037)	0.01	0.09
TLC (Z score)	−0.0028 (0.020)	0.89	0.0294 (0.021)	0.18	0.28
MEF₅₀ (¹⁰log % pred)	−0.0119 (0.0039)	0.005	−0.0159 (0.0053)	0.006	0.53
MEF₂₅ (¹⁰log % pred)	−0.0133 (0.0045)	0.007	−0.0155 (0.0051)	0.005	0.75
FEV₁/FVC (Z score)	−0.0944 (0.026)	0.002	−0.0748 (0.030)	0.02	0.63
RV/TLC (Z score)	0.0231 (0.046)	0.62	0.0763 (0.041)	0.07	0.39
Structure (%)
Composite CT score	1.007 (0.21)	<0.0001	1.547 (0.24)	<0.0001	0.09
Central bronchiectasis	1.253 (0.052)	0.0002	0.978 (0.078)	0.03	0.60
Peripheral bronchiectasis	1.721 (0.049)	<0.0001	1.521 (0.065)	0.0003	0.66
Peripheral mucous plugging	0.652 (0.036)	0.004	0.391 (0.038)	0.08	0.38
Central AWT	1.389 (0.060)	0.0003	1.076 (0.067)	0.008	0.54
Peripheral AWT	0.931 (0.048)	0.002	0.807 (0.053)	0.02	0.76
Opacities	0.733 (0.039)	0.002	0.737 (0.043)	0.006	0.99
Mosaic glass pattern	−0.354 (0.090)	0.58	0.264 (0.085)	0.38	0.38