Table 4

 Comparison of mean (SD) pre- and post-intervention symptom scores and degree of change for participants in the treatment and placebo groups

ScoreGroupPrePostDifference95% CIp value
†Calculated using Wilcoxon signed rank test.
‡Calculated using Mann-Whitney U test.
TotalTreatment†35.4 (16.0)22.7 (18.0)12.7 (12.7)9.0 to 16.1<0.001*
Placebo†29.9 (13.5)28.8 (16.5)2.9 (12.5)−0.7 to 6.50.170
Difference‡8.5 (13.9)4.7 to 14.9<0.001*
BreathingTreatment†7.9 (4.1)5.0 (4.2)2.9 (3.6)1.8 to 3.9<0.001*
Placebo†6.6 (4.7)5.5 (3.5)1.1 (3.4)0.1 to 2.00.004*
Difference‡2.2 (3.7)0.4 to 3.2<0.001*
CoughTreatment†8.8 (2.8)4.9 (3.0)3.9 (3.2)3.0 to 4.9<0.001*
Placebo†7.5 (3.6)6.3 (3.5)1.2 (3.4)0.3 to 2.2<0.001*
Difference‡2.8 (3.6)1.3 to 4.00.003*
VoiceTreatment†7.2 (6.0)4.7 (5.2)2.5 (4.3)1.2 to 3.7<0.001*
Placebo†6.5 (4.6)6.2 (5.0)0.3 (4.1)−0.9 to 1.50.959
Difference‡1.5 (4.5)0.5 to 3.90.005*
Upper airwayTreatment†9.2 (6.6)6.5 (6.3)2.7 (4.7)1.4 to 4.1<0.001*
Placebo†7.4 (4.9)7.4 (5.5)0.1 (4.1)−1.1 to 1.20.946
Difference‡1.5 (4.8)0.9 to 4.40.002*
LimitationTreatment†2.3 (1.2)1.6 (1.0)0.7 (1.1)0.4 to 1.0<0.001*
Placebo†2.2 (1.1)2.0 (1.0)0.3 (0.9)0.0 to 0.60.038*
Difference‡0.5 (1.0)0.0 to 0.80.011*