SFRS8* | Sample 1 | Sample 2 | Sample 1 and 2 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Model | Allele | Fam‡ | S§ | E(S)¶ | p | Allele | Fam | S | E(S) | p | Allele | Fam | S | E(S) | p | |
*Ref Seq NM_004592. | ||||||||||||||||
†Only association to one allele is shown for the additive model due to one degree of freedom in this model. | ||||||||||||||||
‡Number of informative families (families with minimum of one heterozygous parent). | ||||||||||||||||
§FBAT score statistics. | ||||||||||||||||
¶Expected FBAT score statistics, given no association.^{32} For the additive model S can be regarded as observed number of alleles transmitted and E(S) as the expected number of alleles transmitted, given no association. | ||||||||||||||||
**Association not tested if number of informative families <10. | ||||||||||||||||
††p values in parentheses are calculated using the empirical variance, which means H_{0} = linkage but no association.^{34} p values ⩽0.05 are shown in bold. | ||||||||||||||||
rs1379049 | Additive† | g | 19 | 20 | 18 | 0.50 | g | 52 | 50 | 56 | 0.26 | g | 71 | 70 | 74 | 0.51 |
Recessive | g | 1 | ** | g | 9 | ** | g | 10 | 4 | 4.75 | 0.69 | |||||
Recessive | a | 19 | 14 | 16.5 | 0.39 | a | 52 | 49 | 43.25 | 0.23 | a | 71 | 63 | 59.75 | 0.56 | |
rs3782288 | Additive | g | 19 | 48 | 50 | 0.50 | g | 52 | 143 | 136 | 0.19 | g | 71 | 191 | 186 | 0.42 |
Recessive | g | 19 | 14 | 16.5 | 0.39 | g | 52 | 50 | 43.75 | 0.19 | g | 71 | 64 | 60.25 | 0.50 | |
Recessive | a | 1 | ** | a | 10 | 4 | 4.75 | 0.69 | a | 11 | 4 | 5.25 | 0.53 | |||
rs930863 | Additive | c | 28 | 65 | 64.5 | 0.90 | c | 105 | 211 | 214.5 | 0.66 | c | 133 | 276 | 279 | 0.74 |
Recessive | c | 23 | 19 | 19 | 1.00 | c | 80 | 63 | 58.75 | 0.46 | c | 103 | 82 | 77.75 | 0.52 | |
Recessive | a | 11 | 7 | 7.5 | 0.81 | a | 57 | 46 | 38.25 | 0.11 | a | 68 | 53 | 45.75 | 0.17 | |
rs1051219 | Additive | t | 26 | 63 | 64 | 0.78 | t | 85 | 184 | 190.5 | 0.35 | t | 111 | 247 | 254 | 0.34 |
Recessive | t | 23 | 20 | 20.25 | 0.94 | t | 79 | 58 | 58 | 1.00 | t | 102 | 78 | 78.25 | 0.97 | |
Recessive | c | 6 | ** | c | 29 | 23 | 16.5 | 0.050 (0.12)†† | c | 35 | 27 | 19.75 | 0.043 (0.10) | |||
rs1107871 | Additive | g | 28 | 56 | 61 | 0.25 | g | 110 | 222 | 224 | 0.80 | g | 138 | 278 | 285 | 0.45 |
Recessive | g | 24 | 16 | 17.5 | 0.64 | g | 86 | 62 | 62 | 1.00 | g | 111 | 78 | 79.5 | 0.82 | |
Recessive | a | 15 | 12 | 8.5 | 0.14 | a | 58 | 40 | 38 | 0.68 | a | 73 | 52 | 46.5 | 0.30 | |
rs1051233 | Additive | c | 26 | 62 | 64.5 | 0.48 | c | 83 | 187 | 192.5 | 0.41 | c | 109 | 249 | 257 | 0.29 |
Recessive | c | 23 | 19 | 20.5 | 0.64 | c | 78 | 61 | 60.25 | 0.89 | c | 101 | 80 | 80.75 | 0.91 | |
Recessive | g | 5 | ** | g | 22 | 18 | 11.75 | 0.025 (0.079) | g | 27 | 22 | 14.75 | 0.018 (0.057) | |||
rs755437 | Additive | c | 29 | 54 | 56 | 0.63 | c | 112 | 239 | 217 | 0.0068 (0.017) | c | 141 | 293 | 273 | 0.028 (0.050) |
Recessive | c | 21 | 12 | 14.75 | 0.34 | c | 82 | 76 | 58.25 | 0.0020 (0.0079) | c | 103 | 88 | 73 | 0.020 (0.043) | |
Recessive | t | 16 | 11 | 11.75 | 0.77 | t | 65 | 38 | 42.25 | 0.40 | t | 81 | 49 | 54 | 0.38 |