Table 1

 Characteristics of children with cystic fibrosis and healthy controls

CFA (n = 16)CFB (n = 24)Healthy (n = 12)
SD, standard deviation; BAL, bronchoalveolar lavage; TB, tracheobronchial brushing; TCC, total cell count per ml BAL fluid; CFA, CF without bacterial infection at actual or previous BAL; CFB, CF with bacterial infection either in present or previous BAL.
*Mean (SD).
†Geometric mean (95% confidence interval).
‡Cystic fibrosis clinical score.15
¶ Heterozygote mutations included: unknown mutation (n = 5), N310, G551D, R117(H, R553X, P67L, S1235R, W1282 (n = 1).
§This patient was compound heterozygote with one unidentified allele and a positive sweat test.
Age (years)*1.15 (0.83)2.7 (1.5)3.3 (1.2)
M/F9/711/138/4
Symptom score‡13.5 (2.2)14.6 (2.7)NA
Cells from TB (×106)*1.84 (0.67)1.9 (1.07)1.52 (0.7)
Genotype
    dF508 homozygote50%66.7%NA
    dF508 heteroygote¶43.75%29.2%
    G542X/G542X4.2%
    Others§6.25%
Cells in BAL fluid
    TCC (cells×103/ml)†345.3 (236 to 506)443.5 (285 to 690)NA
    Neutrophils (cells ×103/ml)†55.9 (29.5 to 105.9)88.4 (43.2 to 181.1)
    Neutrophils (%)*22.6 (18.9)28.3 (23.2)
iNOS expression†0.23 (0.11 to 0.46)0.22 (0.14 to 0.34)0.76 (0.51 to 1.14)