Table 3

 Mechanisms of the exaggerated response in asthma exacerbation

TriggerEffectMechanism
IFN, interferon.
VirusEnhanced lower airway damageDeficient IFN-β response
AllergenEnhanced eosinophil responseAllergic sensitisation
OccupationalIncreased eosinophilic and/or neutrophilic bronchitisSensitisation
PollutionNeutrophilic bronchitis?
Medication: aspirinSevere bronchospasm?