Table 2

 Characteristics of the airway response in asthma exacerbation

TriggerAirway responseMechanism
IL, interleukin; 5-LO, 5 lipoxygenase; Th, T helper.
VirusNeutrophilic bronchitisEpithelial chemokine activation
AllergenEosinophilic bronchitisTh2 lymphocyte activation with IL-5 release
OccupationalEosinophilic and/or neutrophilic bronchitisNot known
PollutionNeutrophilic bronchitisEpithelial/macrophage chemokine activation
Medication: aspirinSevere bronchospasmArachidonic acid shunting via 5-LO pathway, increased leukotriene production