Variable* | Emphysema(n = 10) | No emphysema(n = 15) | p value |
---|---|---|---|
MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor metalloproteinase-1; NS, not significantly different; OD, optical density; NE, neutrophil elastase. | |||
*Variables measured in sputum except where indicated otherwise. | |||
Data are presented as median (interquartile range); comparisons made using Mann-Whitney U test. | |||
MMP-9 (ng/ml) | 220.9 (175.5–293.3) | 72.2 (41.9–165.4) | 0.04 |
TIMP-1 (ng/ml) | 2.3 (1.4–19.7) | 7.5 (4.5–12.7) | NS |
MMP-9/TIMP-1 ratio | 58.7 (20.1–171.5) | 7.6 (4.3–28.2) | 0.01 |
MMP-9 activity (OD × mm2/protein mg/ml) | 6.1 (4.2–7.9) | 5.7 (3.7–7.4) | NS |
NE activity (U/ml) | 0.01 (0–0.29) | 0 (0–0) | NS |
Desmosines (ng/mg protein) | 12.2 (8.0–13.1) | 6.3 (5.8–13.0) | NS |
Urinary desmosines (μg/g creatinine) | 55.8 (37.7–74.3) | 38.7 (34.3–54.9) | NS |
Plasma desmosines (ng/ml) | 40.0 (22.8–57.0) | 29.5 (20.5–40.9) | NS |