Incidence rates and adjusted hazard ratios (HRs) of stroke in relation to asthma variables: ARIC, 1987–2000
| Asthma definition | No of events | Incidence rate* | Model 1 HR† | 95% CI | Model 2 HR‡ | 95% CI |
|---|---|---|---|---|---|---|
| Maximum number of person-years was 13 522 and maximum number of events was 438. Some subgroups have less because of missing data. | ||||||
| *Crude (per 1000 person-years). | ||||||
| †Model 1 adjusted for age, sex, race/centre. | ||||||
| ‡Model 2 adjusted for age, sex, race/centre, HDL cholesterol, LDL cholesterol, systolic blood pressure, hypertension medication use, smoking status, pack years, W/H ratio, diabetes diagnosis, and sport score. | ||||||
| Never | 403 | 2.69 | 1.0 | – | 1.0 | – |
| Ever | 35 | 4.22 | 1.65 | 1.17 to 2.33 | 1.50 | 1.04 to 2.15 |
| Former | 14 | 3.50 | 1.38 | 0.81 to 2.35 | 1.44 | 0.84 to 2.46 |
| Current | 20 | 4.80 | 1.93 | 1.23 to 3.02 | 1.55 | 0.95 to 2.52 |
| Asthma duration | ||||||
| Never | 403 | 2.69 | 1.0 | – | 1.0 | – |
| Current or former | ||||||
| ⩽20 years | 17 | 3.33 | 1.38 | 0.85 to 2.24 | 1.40 | 0.86 to 2.28 |
| >20 years | 13 | 5.02 | 2.07 | 1.16 to 3.49 | 1.53 | 0.81 to 2.87 |
| Time dependent | ||||||
| No asthma | 394 | 2.77 | 1.0 | – | 1.0 | – |
| Asthma | 44 | 2.79 | 1.44 | 1.06 to 1.97 | 1.43 | 1.03 to 1.98 |
| Wheeze attack | ||||||
| No wheeze attack with shortness of breath | 374 | 2.62 | 1.00 | – | 1.00 | – |
| Wheeze attack with shortness of breath | 64 | 4.09 | 1.57 | 1.21 to 2.06 | 1.56 | 1.18 to 2.06 |