Healthy smokers(n = 14) | COPD with moderate HA(n = 12) | COPD with high HA(n = 6) | |
---|---|---|---|
Values are expressed as median (range). | |||
COPD, chronic obstructive pulmonary disease; HA, hyaluronan; PMN, polymorphonuclear leucocytes. | |||
The Kruskal-Wallis H test was used to test for differences between groups and, if appropriate (p<0.05), subsequent analysis of subgroups was performed using the Mann-Whitney U test. | |||
*p<0.05, **p<0.005 v healthy smokers. | |||
†p<0.005 v COPD patients with moderate HA levels. | |||
Total cell count (106 cells/ml) | 3.1 (0.3–15.7) | 2.2 (0.3–6.1) | 8.5 (4.5–92.0)*† |
Lung macrophages (106 cells/ml) | 0.9 (0.2–4.6) | 0.4 (0.1–0.8)* | 0.6 (0.1–5.5) |
PMN (106 cells/ml) | 1.9 (0.1–10.9) | 1.6 (0.2–5.5) | 7.8 (3.8–86.5)**† |
Eosinophils (106 cells/ml) | 0.0 (0.0–0.2) | 0.0 (0.0–0.1) | 0.0 (0.0–0.2) |
Lymphocytes (106 cells/ml) | 0.0 (0.0–0.1) | 0.0 (0.0–0.0) | 0.0 (0.0–0.4) |