Table 3

 Multivariable logistic model of factors predicting pulmonary exacerbation during the first year of follow up

Patient characteristicOdds ratio (95% CI)p value
FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; BMI, body mass index.
Age0.93 (0.89 to 0.97)0.002
Female sex1.37 (0.69 to 2.72)0.37
BMI (kg/m2)0.92 (0.83 to 1.01)0.07
Lung function
    FEV1 (% predicted)0.97 (0.94 to 1.00)0.05
    FVC (% predicted)1.02 (0.99 to 1.05)0.14
CF related diabetes mellitus0.81 (0.36 to 1.81)0.61
Courses of IV antibiotics for pulmonary exacerbation in past 24 months
    0
    12.30 (0.99 to 5.31)0.05
    2–37.74 (2.94 to 20.39)<0.0001
    >320.81 (6.37 to 67.92)<0.0001
<0.0001 (trend)
Bacteria in sputum at enrolment
    Burkholderia cepacia complex (BC)0.96 (0.30 to 3.09)0.94
    Pseudomonas aeruginosa (PA)0.79 (0.25 to 2.47)0.68
    Both BC and PA0.63 (0.10 to 4.00)0.63
    Other
New bacterial species acquired in sputum during study0.50 (0.13 to 1.93)0.32
Medications used chronically
    Inhaled corticosteroid1.92 (1.00 to 3.71)0.05
    DNase1.24 (0.56 to 2.76)0.59
    Inhaled antibiotics1.46 (0.74 to 2.89)0.28
    Oral antibiotics
        None
        Azithromycin0.28 (0.11 to 0.72)0.01
        Other0.87 (0.31 to 2.46)0.79