Mean (SD) 6MWD and cardiac haemodynamics at baseline and after at least 3 months of treatment with bosentan
| Baseline | 3 months | Change from baseline | p value | |
|---|---|---|---|---|
| 6MWD, 6 minute walk distance; CI, cardiac index; TPR, total pulmonary resistance; PVR, pulmonary vascular resistance; mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure. | ||||
| Two sided p values as indicated. | ||||
| NYHA class II/III/IV | 5/14/1 | 8/11/1 | ||
| 6MWD (m) | 262 (106) | 307 (100) | 45 (53) | 0.001 |
| CI (l/min/m2) | 1.9 (0.62) | 2.3 (0.59) | 0.4 (0.3) | >0.001 |
| TPR (dyne.s/cm5) | 1165 (392) | 918 (275) | −247 (322) | 0.003 |
| PVR (n = 15) (dyne.s/cm5) | 964 (406) | 690 (271) | −274 (300) | 0.005 |
| mPAP (mm Hg) | 48 (13) | 45 (11) | −3 (7.6) | 0.09 |
| mRAP (mm Hg) | 9.4 (6.5) | 7.7 (4.8) | −1.6 (6.6) | 0.28 |
| Mixed venous saturations (%) | 59 (8.6) | 63 (7.7) | 3.8 (9.6) | 0.15 |