Change in lung function per 1 ppb increase in each pollutant showing changes in estimates with adjustment for confounders and of further adjustment for other pollutants
| N | Change in lung function per 1 ppb increase in HONO | p value | N | Change in lung function per 1 ppb (1.91 μg/m3) increase in indoor NO2 | p value | N | Change in lung function per 1 ppb (1.91 μg/m3) increase in outdoor NO2 | p value | |
|---|---|---|---|---|---|---|---|---|---|
| Adjusted1: model includes age, sex, smoking status, pack years of smoking, occupational group, damp observed in the home, centre in which study was conducted, season of HONO measurement, season of lung function testing. Each pollutant examined separately. | |||||||||
| Adjusted2: adjusted1 + HONO + indoor NO2. (Estimates from this single model for HONO and indoor NO2 shown.) | |||||||||
| Adjusted3: adjusted1 + HONO + corrected indoor NO2. (Estimates for HONO shown.) | |||||||||
| Adjusted4: adjusted1 + HONO + indoor NO2 + outdoor NO2. (Estimates from this single model for HONO and indoor NO2 and outdoor NO2 shown.) | |||||||||
| N/A, not applicable. | |||||||||
| FEV1 (% predicted) | |||||||||
| Unadjusted | 192 | −0.84 (−1.60 to −0.07) | 0.03 | 181 | −0.07 (−0.18 to 0.05) | 0.24 | 179 | 0.04 (−0.32 to 0.40) | 0.82 |
| Adjusted1 | 176 | −0.96 (−1.82 to −0.09) | 0.03 | 168 | −0.10 (−0.23 to 0.02) | 0.11 | 166 | 0.25 (−0.74 to 0.23) | 0.31 |
| Adjusted2 | 168 | −1.16 (−2.65 to 0.33) | 0.12 | 168 | 0.03 (−0.18 to 0.25) | 0.77 | 162 | N/A | 0.84 |
| Adjusted3 | 168 | −1.13 (−2.45 to 0.19) | 0.09 | 162 | N/A | 0.73 | N/A | ||
| Adjusted4 | 162 | −1.13 (−2.65 to 0.39) | 0.14 | 162 | 0.04 (−0.19 to 0.27) | −0.06 (−0.65 to 0.53) | |||
| FEV1/FVC ratio (%) | |||||||||
| Unadjusted | 193 | −0.55 (−0.91 to −0.21) | 0.002 | 182 | −0.04 (−0.09 to 0.01) | 0.09 | 180 | −0.06 (−0.23 to 0.10) | 0.44 |
| Adjusted1 | 176 | −0.45 (−0.83 to −0.06) | 0.02 | 168 | −0.05 (−0.10 to 0.01) | 0.11 | 166 | −0.11 (−0.32 to 0.11) | 0.34 |
| Adjusted2 | 168 | −0.57 (−1.23 to 0.09) | 0.09 | 168 | 0.02 (−0.07 to 0.12) | 0.67 | 163 | N/A | 0.94 |
| Adjusted3 | 168 | −0.54 (−1.13 to 0.04) | 0.07 | 163 | N/A | 0.67 | N/A | ||
| Adjusted4 | 163 | −0.56 (−1.25 to 0.12) | 0.07 | 163 | 0.02 (−0.08 to 0.12) | −0.01 (−0.27 to 0.25) | |||