Table 1

 Distribution of TNFα genotypes according to FEV1 % predicted

TNFα SNPGenotype*p value†
*For each genotype the number of individuals with an FEV1 higher or lower than 70% predicted is given with the percentage in parentheses. The analysis was performed by a likelihood ratio χ2 test, or by the Fisher exact probability test (F) when more than 20% of the cells had an expected count of <5.
There may be a difference in number of genotypes typed for the different SNPs because gap filling of data could not always be done successfully.
†Significant results are shown in bold and the odds ratio (OR) is given for significant values.
+691g ins/del ins/insins/delins/ins:ins/del
>70% FEV1 predicted(n = 59)48 (81.4%)11 (18.6%)0.009 (OR = 6.0)
<70% FEV1 predicted(n = 54)52 (96.3%)2 (3.7%)
851c/tccctttcc:ct:ttcc:ct+tt
>70% FEV1 predicted(n = 56)37 (64.9%)19 (33.3%)1 (1.8%)0.07 (F)0.04 (OR = 2.4)
<70% FEV1 predicted(n = 55)45 (81.8%)10 (18.2%)0 (0%)
− 308g/a gggaaagg:ga:aagg:ga+aa
>70% FEV1 predicted(n = 57)43 (75.4%)14 (24.6%)0 (0%)0.15 (F)0.18
<70% FEV1 predicted(n = 54)47 (85.5%)7 (12.7%)1 (1.8%)
− 238g/a gggaaagg:ga:aagg:ga+aa
>70% FEV1 predicted(n = 56)51 (89.5%)5 (8.7%)1 (1.8%)0.8 (F)1.0
<70% FEV1 predicted(n = 54)50 (90.9%)4 (7.3%)1 (1.8%)