TNFα SNP | Genotype* | p value† | |||
---|---|---|---|---|---|

*For each genotype the number of individuals with an FEV_{1} higher or lower than 70% predicted is given with the percentage in parentheses. The analysis was performed by a likelihood ratio χ^{2} test, or by the Fisher exact probability test (F) when more than 20% of the cells had an expected count of <5. | |||||

There may be a difference in number of genotypes typed for the different SNPs because gap filling of data could not always be done successfully. | |||||

†Significant results are shown in bold and the odds ratio (OR) is given for significant values. | |||||

+691g ins/del
| ins/ins | ins/del | ins/ins:ins/del | ||

>70% FEV_{1} predicted(n = 59) | 48 (81.4%) | 11 (18.6%) | 0.009 (OR = 6.0) | ||

<70% FEV_{1} predicted(n = 54) | 52 (96.3%) | 2 (3.7%) | |||

−851c/t | cc | ct | tt | cc:ct:tt | cc:ct+tt |

>70% FEV_{1} predicted(n = 56) | 37 (64.9%) | 19 (33.3%) | 1 (1.8%) | 0.07 (F) | 0.04 (OR = 2.4) |

<70% FEV_{1} predicted(n = 55) | 45 (81.8%) | 10 (18.2%) | 0 (0%) | ||

− 308g/a
| gg | ga | aa | gg:ga:aa | gg:ga+aa |

>70% FEV_{1} predicted(n = 57) | 43 (75.4%) | 14 (24.6%) | 0 (0%) | 0.15 (F) | 0.18 |

<70% FEV_{1} predicted(n = 54) | 47 (85.5%) | 7 (12.7%) | 1 (1.8%) | ||

− 238g/a
| gg | ga | aa | gg:ga:aa | gg:ga+aa |

>70% FEV_{1} predicted(n = 56) | 51 (89.5%) | 5 (8.7%) | 1 (1.8%) | 0.8 (F) | 1.0 |

<70% FEV_{1} predicted(n = 54) | 50 (90.9%) | 4 (7.3%) | 1 (1.8%) |