Table 2

 Response to treatment

MeasurementSildenafil 25 mg (n = 9)Sildenafil 100 mg (n = 5)Placebo (n = 8)
Pre-treatmentWeek 12Pre-treatmentWeek 12Pre-treatmentWeek 12
BaselineBaseline1 h post-doseBaselineBaseline1 h post-doseBaselineBaseline1 h post-dose
mPAP, mean pulmonary artery pressure; SystPAP, systolic pulmonary artery pressure; CO, cardiac output; PVR, pulmonary vascular resistance; WP, wedge pressure; HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; Sao2, systemic arterial oxygen saturation.
mPAP (mm Hg)36 (8)30 (8)25 (7)32 (3)26 (3)21 (2)34 (6)35 (12)35 (11)
Syst PAP (mm Hg)53 (11)47 (13)39 (10)46 (5)41 (6)33 (4)51 (7)55 (19)55 (18)
CO (l/min)5.3 (1.1)5.0 (1.4)5.4 (1.7)5.5 (1.2)6.6 (0.6)6.4 (0.8)4.6 (1.2)5.3 (1.7)5.3 (1.6)
PVR (dyne.s/cm5)441 (242)391 (243)284 (204)328 (58)185 (49)130 (39)457 (146)390 (205)388 (208)
WP (mm Hg)9 (1)9 (2)9 (2)9.6 (2.1)11 (2.8)11 (2.8)9 (2)10 (3)10 (3)
HR (beats/min)66 (8)63 (10)62 (9)74 (12)70 (14)69 (14)61 (5)63 (8)62 (8)
SBP (mm Hg)127 (22)125 (19)124 (17)132 (20)127 (8)125 (7)118 (8)123 (13)123 (13)
DBP (mm Hg)77 (10)78 (7)78 (7)80 (7)81 (2)81 (2)75 (5)75 (6)76 (6)
Sao2 (%)94 (3)95 (2)95 (2)94 (2)95 (1)95 (1)94 (5)94 (5)94 (5)