Table 3

 Demographic data and baseline characteristics of class III idiopathic PAH patients in matched cohorts

NBosentan matched cohort(N = 83)nEpoprostenol matched cohort(N = 83)p value*
mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; PAH, pulmonary arterial hypertension; PVR, pulmonary vascular resistance; SD, standard deviation.
Patients were matched using baseline cardiac index, mPAP, and mRAP (see Methods section in online supplement).
*p values were determined using the Fisher’s exact test (sex) and the Student’s t test (all others).
†For most bosentan treated patients, time from diagnosis and haemodynamic data were available only at the start of the placebo controlled study.
Sex (M/F, %)8324/768328/720.723
Age (years)
    Mean (SD)8346 (16)8343 (13)0.136
Time from diagnosis (months)*
    Mean (SD)8329 (36)2611 (19)0.014
Haemodynamics (mean (SD))†
    Cardiac index (l/min/m2)832.2 (0.6)832.1 (0.6)0.610
    PVR (Wood units)7913 (6)5314 (6)0.553
    mPAP (mm Hg)8357 (15)8359 (15)0.397
    mRAP (mm Hg)8310 (5)8310 (5)0.893
Walk test (m)
    Mean (SD)83355 (76)41350 (110)0.762