Clinical efficacy of treatment in the two treatment groups
| Outcome | PDT | EAT | 95% CI | p value | Odds ratio (95% CI) |
|---|---|---|---|---|---|
| PDT, pathogen directed treatment group; EAT, empirical antibiotic treatment group; 95% CI, 95% confidence interval for difference; LOS, length of stay; ICU, intensive care unit. | |||||
| *95% confidence interval for mean. | |||||
| †Failure within 72 hours of starting antibiotic treatment and thereafter. | |||||
| ‡Failure after 72 hours of treatment. | |||||
| Intention-to-treat population, n | 152 | 151 | |||
| LOS, mean days (CI*) | 14.3 (12.2 to 16.4) | 13.2 (11.7 to 14.7) | −1.5 to 3.7 | 0.75 | |
| Clinical failure, n (%) | 32 (21) | 35 (23) | −12% to 7% | 0.66 | 1.13 (0.66 to 1.95) |
| Mortality, n (%) | 12 (8) | 22 (15) | −14% to 1% | 0.07 | 1.99 (0.95 to 4.18) |
| Evaluable population, n | 134 | 128 | |||
| LOS, mean days (CI) | 13.7 (11.5 to 15.9) | 12.8 (11.1 to 14.5) | −1.9 to 3.7 | 0.63 | |
| Clinical failure, n (%) | 26 (19) | 27 (21) | −12% to 8% | 0.74 | 1.11 (0.61 to 2.03) |
| Mortality, n (%) | 10 (7) | 18 (14) | −14% to 1% | 0.09 | 2.03 (0.90 to 4.58) |
| Early failure†, n (%) | 17 (13) | 15 (12) | −8% to 9% | 0.81 | |
| Adequate antibiotic | |||||
| Treatment, n (%) | 9 (7) | 10 (8) | −7% to 5% | 0.73 | |
| Mortality, n (%) | 4 (3) | 6 (5) | −6% to 3% | 0.47 | |
| Inadequate antibiotic | |||||
| Treatment, n (%) | 8 (6) | 5 (4) | −3% to 7% | 0.44 | |
| Mortality, n (%) | 2 (1) | 4 (3) | −6% to 2% | 0.23 | |
| Late failure‡, n (%) | 9 (7) | 12 (9) | −9% to 4% | 0.43 | |
| Mortality, n (%) | 4 (3) | 8 (6) | −8% to 2% | 0.21 | |
| ICU admission, n (%) | 11 (8) | 11 (9) | −7% to 6% | 0.91 | |
| Mortality, n (%) | 5 (45) | 10 (91) | −84% to −7% | 0.02 | |
| Adequate treatment, n (%) | 4 (80) | 8 (80) | −50% to 50% | 1 | |
| Inadequate treatment, n (%) | 1 (20) | 2 (20) | −50% to 50% | 1 | |
| Clinical failure, n (%) | 8 (73) | 11 (100) | −59% to 4% | 0.08 | |