Comparison of factor scores of serum anti-endothelial and anti-HEp-2 cell IgG and IgM reactivities from IPAH patients and SSc patients with or without PAH
| Antigen sources | Isotype | SSc-PAH v IPAH | SSc-PAH v SSc without PAH | ||
|---|---|---|---|---|---|
| MW of bands contributing to factors (kDa) | p value | MW of bands contributing to factors (kDa) | p value | ||
| For definition of abbreviations see footnote to table 2. | |||||
| *Level of significance of the comparison of the factor scores of patients with controls (Mann-Whitney test). | |||||
| HUVEC | IgG | Factor 1: 32, 50–60 | Factor 1: 0.18 | Factor 1: 28, 32, 50–57 | Factor 1: 0.41 |
| Factor 2: 36, 45 | Factor 2: 0.75 | Factor 2: 36, 45 | Factor 2: 0.58 | ||
| Factor 3: 28, 50, 52 | Factor 3: 0.56 | Factor 3: 52, 60 | Factor 3: 0.09 | ||
| IgM | Factor 1: 48, 55, 70 | Factor 1: 0.71 | Factor 1: 48, 55, 70 | Factor 1: 0.98 | |
| Factor 2: 37, 63, 68 | Factor 2: 0.05 | Factor 2: 63, 68 | Factor 2: 0.13 | ||
| Factor 3: 130 | Factor 3: 0.07 | Factor 3: 130 | Factor 3: <0.01* | ||
| HMVEC-l | IgG | Factor 1: 37, 40, 44 | Factor 1: 0.58 | Factor 1: 28, 37, 55, 58 | Factor 1: 0.81 |
| Factor 2: 63, 75, 77 | Factor 2: 0.35 | Factor 2: 63, 75, 77 | Factor 2: 0.15 | ||
| Factor 3: 28, 68 | Factor 3: 0.26 | Factor 3: 28, 68 | Factor 3: 0.61 | ||
| Factor 4: 55, 58 | Factor 4: 0.08 | Factor 4: 55, 58 | Factor 4: 0.71 | ||
| IgM | Factor 1: 57, 80, 90 | Factor 1: 0.11 | Factor 1: 48, 65 | Factor 1: 0.18 | |
| Factor 2: 32, 48, 65 | Factor 2: 0.97 | Factor 2: 32, 78, 80 | Factor 2: 0.98 | ||
| Factor 3: 100, 110 | Factor 3: 0.12 | Factor 3: 58, 90, 100, 110 | Factor 3: 0.81 | ||
| HMVEC-d | IgG | Factor 1: 32–45 | Factor 1: 0.82 | Factor 1: 28–45, 58, 63, 75 | Factor 1: 0.02* |
| Factor 2: 28, 32, 63 | Factor 2: 0.36 | Factor 2: 85, 100 | Factor 2: 0.71 | ||
| Factor 3: 75, 85 | Factor 3: 0.33 | ||||
| Factor 4: 58, 100 | Factor 4: <0.01* | ||||
| IgM | Factor 1: 38–43, 55, 90 | Factor 1: 0.58 | Factor 1: 38–43, 90 | Factor 1: 0.18 | |
| Factor 2: 73–77 | Factor 2: 0.82 | Factor 2: 73–77 | Factor 2: 0.47 | ||
| Factor 3: 55 | Factor 3: 0.3 | ||||
| HEp-2 | IgG | Factor 1: 28, 36, 45, 75 | Factor 1: 0.21 | Factor 1: 27, 58, 62, 75, 100 | Factor 1: 0.49 |
| Factor 2: 58, 62 | Factor 2: 0.02* | Factor 2: 28, 31, 36, 45 | Factor 2: 0.26 | ||
| Factor 3: 27, 31 | Factor 3: 0.90 | Factor 3: 32 | Factor 3: 0.98 | ||
| Factor 4: 100 | Factor 4: 0.58 | ||||
| IgM | Factor 1: 32, 45, 50, 73, 75 | Factor 1: 0.78 | Factor 1: 25, 28, 45, 50, 55 | Factor 1: 0.95 | |
| Factor 2: 65, 68 | Factor 2: 0.5 | Factor 2: 65, 68 | Factor 2: 0.61 | ||
| Factor 3: 25, 28, 55 | Factor 3: 0.8 | Factor 3: 73, 77 | Factor 3: 0.09 | ||