Comparison of factor scores of serum anti-endothelial and anti-HEp-2 cell IgG and IgM reactivities from patients with PAH and their respective controls
| Antigen source | Isotype | PAH | IPAH | SSc-PAH | |||
|---|---|---|---|---|---|---|---|
| MW of bands contributing to factors(kDa) | p value | MW of bands contributing to factors(kDa) | p value | MW of bands contributing to factors(kDa) | p value | ||
| For definition of abbreviations see footnote to table 2. | |||||||
| *Level of significance of the comparison of the factor scores of patients with controls (paired Wilcoxon test). | |||||||
| HUVEC | IgG | Factor 1: 32, 50–60 | Factor 1: 0.89 | Factor 1: 50–60 | Factor 1: 0.02* | Factor 1: 58–60 | Factor 1: 0.92 |
| Factor 2: 28, 32, 36 | Factor 2: 0.24 | Factor 2: 28, 32, 36 | Factor 2: <0.01* | Factor 2: 36–45 | Factor 2: 0.85 | ||
| Factor 3: 45, 48 | Factor 3: 0.52 | Factor 3: 45, 48 | Factor 3: <0.01* | Factor 3: 50–52 | Factor 3: 0.13 | ||
| Factor 4: 28, 32, 58 | Factor 4: 0.72 | ||||||
| IgM | Factor 1: 37, 48, 55, 70 | Factor 1: 0.74 | Factor 1: 37, 48, 55, 70 | Factor 1: 0.82 | Factor 1: 63, 68, 130 | Factor 1: 0.01* | |
| Factor 2: 63, 68 | Factor 2: 0.03* | Factor 2: 63, 68 | Factor 2: 0.32 | Factor 2: 37, 48, 70 | Factor 2: 0.92 | ||
| Factor 3: 130 | Factor 3: 0.04* | Factor 3: 130 | Factor 3: 0.66 | Factor 3: 55 | Factor 3: 0.62 | ||
| HMVEC-l | IgG | Factor 1: 37, 40, 44, 68 | Factor 1: <0.01* | Factor 1: 37, 40, 44, 68 | Factor 1: <0.01* | Factor 1: 28, 37, 55 | Factor 1: 0.32 |
| Factor 2: 75, 77 | Factor 2: 0.19 | Factor 2: 75, 77 | Factor 2: 0.44 | Factor 2: 68, 75, 77 | Factor 2: 0.16 | ||
| Factor 3: 44, 55, 58, 63 | Factor 3: <0.01* | Factor 3: 58, 63 | Factor 3: 0.82 | Factor 3: 40, 44, 63 | Factor 3: 0.1 | ||
| IgM | Factor 1:32, 48, 65, 80 | Factor 1: 0.97 | Factor 1: 32, 48, 65, 80 | Factor 1: 0.79 | Factor 1: 58, 90, 100, 110 | Factor 1: 0.37 | |
| Factor 2: 58, 80, 90 | Factor 2: 0.69 | Factor 2: 58, 80, 90 | Factor 2: 0.98 | Factor 2: 32, 48, 65, 78, 80 | Factor 2: 0.92 | ||
| Factor 3: 100, 110 | Factor 3: 0.4 | Factor 3: 100, 110 | Factor 3: 0.55 | ||||
| HMVEC-d | IgG | Factor 1: 28–45 | Factor 1: <0.01* | Factor 1: 32–45 | Factor 1: <0.01* | Factor 1: 28–45, 58 | Factor 1: 0.37 |
| Factor 2: 58, 63, 100 | Factor 2: <0.01* | Factor 2: 75, 85 | Factor 2: 0.02* | Factor 2: 63, 85 | Factor 2: 0.66 | ||
| Factor 3: 75, 85 | Factor 3: 0.03* | Factor 3: 28, 58, 63 | Factor 3: <0.01* | Factor 3: 75, 100 | Factor 3: 0.49 | ||
| IgM | Factor 1: 38–43, 55, 90 | Factor 1: 0.63 | Factor 1:38–43, 55, 90 | Factor 1: 0.74 | Factor 1: 38–43, 55, 90 | Factor 1: 0.69 | |
| Factor 2: 73–77 | Factor 2: 0.36 | Factor 2: 73–77 | Factor 2: 0.36 | Factor 2: 73–77 | Factor 2: 0.92 | ||
| HEp-2 | IgG | Factor 1: 27, 31, 32 | Factor 1: <0.01* | Factor 1: 27, 31, 36 | Factor 1: 0.01* | Factor 1: 28, 36, 45, 75 | Factor 1: 0.16 |
| Factor 2: 58, 62 | Factor 2: 0.03* | Factor 2: 58, 62 | Factor 2: 0.44 | Factor 2: 27, 32 | Factor 2: 0.37 | ||
| Factor 3: 28, 45 | Factor 3: 0.5 | Factor 3: 28, 45 | Factor 3: 0.84 | Factor 3: 28, 45 | Factor 3: <0.01* | ||
| Factor 4: 100 | Factor 4: 0.02* | Factor 4: 32, 75, 100 | Factor 4: <0.01* | Factor 4: 100 | Factor 4: 0.77 | ||
| IgM | Factor 1: 32, 45, 50, 73, 75 | Factor 1: 0.1 | Factor 1: 32, 45, 50, 73, 75 | Factor 1: 0.06 | Factor 1: 55, 65, 68, 75 | Factor 1: 0.37 | |
| Factor 2: 55, 65, 68 | Factor 2: 0.27 | Factor 2: 25, 28 | Factor 2: 0.24 | Factor 2: 25, 28, 32, 45, 50, 73, 75 | Factor 2: 0.85 | ||
| Factor 3: 25, 28 | Factor 3: 0.63 | Factor 3: 55, 65 | Factor 3: 0.23 | ||||