Muscle force and exercise capacity in patients with sarcoidosis and healthy subjects
| Sarcoidosis | Healthy subjects | Differences between means (95% CI) | p value | |||
|---|---|---|---|---|---|---|
| Values are expressed as mean (SD) and as the differences between means (with 95% CI). Pimax, maximal inspiratory pressure; Pemax, maximal expiratory pressure; HGF, handgrip force; kgF, kilogram force; QPT, quadriceps peak torque; Nm, Newton-meter; 6MWD, distance walked in 6 minutes; Vo2, oxygen uptake; HR, heart rate; % HRmax pred, percentage of maximal heart rate predicted; Ve, ventilation; MVV, maximum voluntary ventilation. | ||||||
| Muscle force | ||||||
| Pimax (cm H2O) | −89 (31) | −115 (33) | −26 (−45 to −5) | 0.01 | ||
| Pimax (% predicted) | 79 (21) | 104 (28) | 25 (10 to 40) | 0.002 | ||
| Pemax (cm H2O) | 157 (53) | 205 (53) | 49 (16 to 81) | 0.004 | ||
| Pemax (% predicted) | 84 (20) | 112 (19) | 28 (16 to 40) | 0.0001 | ||
| HGF (kgF) | 38 (13) | 45 (13) | 7 (−1 to 16) | 0.07 | ||
| HGF (% predicted) | 87 (22) | 104 (16) | 17 (5 to 28) | 0.007 | ||
| QPT (Nm) | 142 (62) | 187 (56) | 45 (9 to 81) | 0.02 | ||
| QPT (% predicted) | 67 (22) | 95 (16) | 29 (17 to 41) | 0.0001 | ||
| Functional exercise test | ||||||
| 6MWD (m) | 605 (131) | 788 (106) | 183 (109 to 256) | 0.0001 | ||
| 6MWD (% predicted) | 79 (13) | 102 (11) | 23 (16 to 31) | 0.0001 | ||
| Dyspnoea 6MWD (points) | 3.7 (1.8) | 1.9 (1.2) | −1.8 (−2.7 to −0.8) | 0.0006 | ||
| Fatigue 6MWD (points) | 4.6 (2.5) | 3.6 (1.7) | −0.9 (−2.2 to 0.4) | 0.18 | ||
| Peak exercise test | ||||||
| Peak load (watt) | 165 (54) | 230 (72) | 65 (26 to 104) | 0.002 | ||
| Peak load (% predicted) | 84 (17) | 123 (22) | 40 (28 to 52) | 0.0001 | ||
| Peak Vo2 (ml/kg/min) | 25 (9) | 36 (10) | 11 (5 to 17) | 0.001 | ||
| Peak Vo2 (% predicted) | 85 (24) | 109 (15) | 24 (12 to 37) | 0.0003 | ||
| Peak HR (% HRmax pred) | 95 (9) | 101 (6) | 6 (1 to 11) | 0.02 | ||
| Peak Ve (% MVV) | 74 (17) | 71 (12) | −3 (−12 to 6) | 0.53 | ||
| Lactate (mmol/l) | 9.8 (2.9) | 11.7 (3.1) | 1.9 (−0.2 to 4.0) | 0.08 | ||
| Dyspnoea cycle (points) | 5.9 (1.9) | 4.9 (2.0) | −1.0 (−2.2 to 0.3) | 0.14 | ||
| Fatigue cycle (points) | 7.4 (1.9) | 6.3 (1.6) | −1.1 (−2.2 to 0.0) | 0.05 | ||