Summary of lung function studies in IPF
| Author | Subset | N | Age (years) | FVC | Tlco | (Survival months) | Result |
|---|---|---|---|---|---|---|---|
| Subset refers to whether the authors specified the histological subset studied. | |||||||
| Age and FVC/Tlco are median values; survivals are mean values. | |||||||
| LF, lung function; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; TLC, total lung capacity; Tlco, carbon monoxide transfer factor; UIP, usual interstitial pneumonia; NSIP; non-specific interstitial pneumonia. | |||||||
| Schwartz12 | No | 38 | 62 | 67% | 46% | NA | Decreased TLC/Tlco associated with dyspnoea |
| Schwartz12 | No | 74 | 67 | 62% | 44% | 60 | Increased FEV1/FVC ratio |
| Hanson13 | No | 58 | 59 | 61% | 42% | 88 | 1 year: 10% drop FVC, 20% drop Tlco: increased mortality |
| Erbes11 | No | 99 | 53 | 89% | 46% | 41 | Reduced TLC |
| Hubbard9 | No | 244 | 69 | 78% | 49% | 34 | No LF variable associated with mortality |
| Gay17 | Yes | 38 | 54 | UIP 69% | UIP 50% | 26 | No LF variable associated with mortality |
| Mogulkoc19 | Yes | 115 | 55 | UIP 72% | UIP 49% | 50 | Tlco 39% predicted: 80% sensitivity/specificity 2 year survival |
| Wells27 | Yes | 197 | 62 | UIP 68% | 36% | 22 | Mortality associated with reduced Tlco, FVC, TLC |
| Latsi20 | Yes | 104 | 55 | UIP 72%NSIP 73% | UIP 46%NSIP 41% | UIP 33 NSIP 56 | Tlco 35% predicted: early mortality |
| Collard22 | Yes | 81 | 61 | UIP 67% | UIP 52% | 51 | Reduced survival: 10% drop in FVC 6 months |
| Flaherty21 | Yes | 80 | 62 | UIP 67%NSIP 71% | UIP 50%NSIP 48% | 69 (total group) | Reduced survival: 10% drop in FVC/6 months |