Table 2

 Induced sputum cell counts and mediator concentrations

NormalHypothyroid
Data expressed as median (25–75th percentile) except where indicated: †geometric mean (log SE); ‡mean (SE); absolute cell counts ×104/g sputum.
*p<0.05 (Mann-Whitney test).
Exhaled nitric oxide (ppb)†1.4 (0.2)3.2 (0.1)
Interleukin-8 (ng/ml)3.3 (2.2–9.7)11 (4.9–28.5)*
Histamine (ng/ml)10.8 (2.1–36.0)3.8 (1.7–33.1)
Absolute cell counts (×104/g)
    Neutrophils54.7 (10.4–122.2)117.5 (65.3–275.6)*
    Eosinophils0.0 (0–0.6)1.5 (0–4.5)
    Lymphocytes0.1 (0–1.3)1.5 (0–4.5)*
    Macrophages10.0 (2.2–93.4)36.4 (11.4–93.4)
    Epithelial cells0.5 (0–4.5)2.9 (0.8–8.3)
Total cell count (× 106/ml)0.5 (0.2–2.0)2.1 (1.1–3.3)*
Differential cell counts (%)
    Neutrophils64.0 (52.9–85.2)69.4 (59.7–88.2)
    Eosinophils0.3 (0–0.4)0.5 (0.1–1.7)
    Lymphocytes0.6 (0–0.8)1.0 (0.2–1.5)
    Macrophages34.8 (13.0–44.9)22.7 (6.6–31.8)
    Epithelial cells1.0 (0.1–2.7)1.6 (0.4–3.8)
Viability (%)‡46 (6)68 (4)
Squamous cell contamination (%)‡14 (4)10 (6)