Table 1

 Subject characteristics and pulmonary function tests

NormalHypothyroid
Data expressed as mean (SE).
Positive thyroid autoantibody, thyroid peroxidase titre >1:60; n, number; NR, normal range; TSH, thyroid stimulating hormone; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; RV, residual volume; TLC, total lung capacity; Tlco, carbon monoxide transfer factor; Kco, carbon monoxide transfer coefficient; PC20, provocative concentration of methacholine.
*p<0.05; **p<0.001 (χ2 test).
N (male)19 (0)26 (0)
Age (years)48 (3)52 (3)
Body mass index (kg/m2)24.0 (0.4)28.8 (1.0)**
Ex-smokers (n)64
Pack year smoking in ex-smokers23
Serum T4 (NR 10–25 pmol/l)14.1 (0.4)16.7 (0.5)**
TSH (NR 0.3–5.0 mU/l)2.2 (0.5)1.9 (0.5)
Duration of hypothyroidism (years)11 (2)
Positive thyroid autoantibodies,n (%)1 (5)25 (96)**
Atopy, n (%)4 (21)5 (19)
Cough, n (%)3 (16)12 (46)*
Breathlessness, n (%)2 (11)12 (46)*
Sputum, n (%)09 (35)**
Wheeze, n (%)05 (19)*
FEV1 (% predicted)110 (3)110 (4)
FEV1/FVC (%)83 (1)81 (2)
RV (% predicted)83 (3)85 (4)
TLC (% predicted)98 (2)102 (2)
Tlco (% predicted)99 (3)98 (3)
Kco (% predicted)104 (2)103 (2)
PC20 FEV1 <8 mg/ml(% of subjects)038*