Table 2

 Geometric mean (range) bronchial responsiveness data

Healthy subjects(n = 10)Asthma (no ICS)(n = 10)Asthma (ICS)(n = 10)
MCh, methacholine; PD10, PD15, PD20, provocative dose causing 10%, 15% and 20% decrease in FEV1; nd, could not be determined.
PD20LTD4 (nmol)14.12 (6.47–40.37)(n = 7)0.74 (0.06–6.43)0.65 (0.15–37.05)
PD20MCh (nmol)nd913 (89–25457)862 (89–37188)
Ratio PD20MCh/PD20LTD4nd1234 (174–17557)1326 (206–5825)
PD15LTD4 (nmol)16.50 (2.9–192.1)(n = 9)0.41 (0.04–5.17)0.41 (0.07–12.27)
Ratio PD15LTD4 healthyv asthma40.2 (16.5/0.41)(n = 29)
PD15MCh (nmol)nd659 (89–19316)582 (89–27298)
Ratio PD15MCh/PD15LTD4nd1607 (575–30181)1420 (240–5982)
PD10LTD4 (nmol)7.14 (1.14–54.24)0.18 (0.01–1.25)0.22 (0.04–5.00)
Ratio PD10LTD4 healthyv asthma35.7 (7.14/0.20)(n = 30)
PD10MCh (nmol)12 974 (3830–47351)(n = 7)330 (89–2430)270 (89–9819)
Ratio PD10MCh healthyv asthma43.2 (12974/300)(n = 27)
Ratio PD10MCh/PD10LTD41827 (321–7399)(n = 7)1852 (832–18743)1238 (116–4746)