Table 1

 Subject characteristics

Healthy(n = 10)Asthma (no ICS)(n = 10)Asthma (ICS)(n = 10)
FEV1, forced expiratory volume in 1 second; ICS, inhaled corticosteroid; SABA, short acting β agonist; SPT, skin prick test; Feno, fraction of exhaled nitric oxide; QoL, quality of life.
Lung function data at baseline (visit 1).
F/M5/55/56/4
Mean (SD) age (years)35 (10.1)32 (8.6)31 (6.9)
Mean (SD) FEV1 (l)4.1 (0.7)3.2 (0.6)3.3 (1.0)
Mean (SD) FEV1 (% predicted)110 (11.6)90 (9.4)91 (14.7)
MedicationSABABudesonide + SABA (n = 9; daily dose 400 μg n = 7, 800 μg n = 1, 1200 μg n = 1)
Fluticasone propionate 500 μg + SABA (n = 1)
Mean (SD) SPT (out of 10)3 (2.1)3 (2.3)
Median (range) Feno11.0 (6.3–19.7)n = 925.2 (6.8–198.6)n = 817.2 (6.1–86.5)n = 9
Mean (SD) asthma specific QoL5.9 (0.88)6.0 (0.73)