Risk factors for squamous cell carcinoma
| Risk factors | Univariate analysis | Logistic regression | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases (n = 86) | Controls (n = 54) | OR | 95% CI | p value | OR | 95% CI | p value | |
| *Compared with more peripheral localisation. | ||||||||
| FEV1 = forced expiratory volume in 1 second; OR = odds ratio; CI = confidence intervals. | ||||||||
| Sex (F/M) | 9/77 | 9/45 | 0.78 | 0.46 to 2.04 | 0.74 | 0.92 | 0.26 to 2.98 | 0.92 |
| Age | 70.7 (5.8) | 69.2 (4.5) | 0.97 | 0.93 to 1.11 | 0.57 | 0.98 | 0.94 to 1.04 | 0.66 |
| Ex-smokers, n (%) | 51 (59.4%) | 34 (63.0%) | 0.80 | 0.57 to 2.49 | 0.92 | 0.71 | 0.45 to 3.16 | 0.73 |
| Pack years | 47.9 (8.7) | 46.0 (7.6) | 1.02 | 0.99 to 1.02 | 0.76 | 1.01 | 0.99 to 1.02 | 0.58 |
| FEV1 | 77.2 (2.8) | 82.7 (4.1) | 0.98 | 0.90 to 1.00 | 0.53 | 0.99 | 0.98 to 1.02 | 0.72 |
| Chronic bronchitis, n (%) | 38 (44.1%) | 39 (72.2%) | 0.30 | 0.14 to 0.63 | <0.001 | 0.26 | 0.09 to 0.52 | 0.001 |
| COPD, n (%) | 61 (70.9%) | 23 (42.5%) | 3.28 | 1.61 to 6.70 | <0.001 | 4.05 | 1.93 to 10.57 | 0.001 |
| Tumour localisation | ||||||||
| Main bronchus, n (%) | 3 (3.4%) | 1 (1.8%) | 4.87* | 0.43 to 55.3* | 0.20* | 5.59* | 0.38 to 82.6* | 0.21* |
| Lobar bronchus, n (%) | 17 (19.7%) | 9 (16.6%) | 3.03* | 0.93 to 10.1* | 0.066* | 2.05* | 0.57 to 7.70* | 0.29* |
| Segmental bronchus, n (%) | 53 (61.6%) | 26 (48.1%) | 3.13* | 1.22 to 8.99* | 0.019* | 2.92* | 0.98 to 8.68* | 0.054* |
| Subsegmental bronchus, n (%) | 4 (4.6%) | 6 (11.1%) | 1.08* | 0.23 to 5.11* | 0.92* | 1.96* | 0.33 to 11.5* | 0.47* |
| More peripheral, n (%) | 9 (10.4%) | 12 (22.2%) | – | – | – | – | – | – |