Table 1

 Clinical and physiological characteristics of study subjects

Age (years)†Sex (M/F)FEV1 (% predicted)†FVC (% predicted)†FEV1/FVC (%)†Methacholine PD20 (mg)‡
Data are presented as †mean (SD) and ‡geometric mean (range).
Comparisons between asthmatic and control groups and between stable CF and control groups were performed using an unpaired t test. Within subject comparisons of spirometric measurements for the eight CF patients studied in exacerbation were undertaken with a paired t test.
*p = 0.002 v control group; **p<0.001 v control group.
Control (n = 15)39 (10)6/9103 (15)107 (16)82 (5)>1.5
Asthma (n = 12)38 (16)7/579 (18)**102 (16)66 (12)0.068 (<0.0256–1.3)
CF stable (n = 18)24 (8)**11/768 (25)**88 (17)*65 (16)**
CF exacerbation (n = 8)28 (9)4/458 (25)82 (20)59 (17)