Histochemistry and enzymology of peripheral muscle
| COPD(n = 16) | Healthy subjects(n = 16) | Mean difference(95% CI) | p value | |
|---|---|---|---|---|
| Values are mean (SE). | ||||
| CS, citrate synthase; HADH, 3-hydroxyacyl CoA dehydrogenase; HK, hexokinase; LDH, lactate dehydrogenase; PFK, phosphofructokinase. | ||||
| Relative proportion of fibre (%) | ||||
| Type I | 27 (3) | 58 (3) | 31 (20 to 41) | <0.001 |
| Type IIa | 32 (4) | 29 (3) | 2 (−11 to 15) | NS |
| Type IIx | 22 (4) | 8 (2) | 14 (2 to 26) | <0.05 |
| Type IIax | 19 (1) | 5 (1) | 3.8 (−2 to 10) | NS |
| Enzyme activities (μmol/min/g) | ||||
| CS | 23.7 (0.5) | 27.6 (0.8) | 3.8 (1.4 to 6.2) | <0.01 |
| HADH | 5.0 (0.2) | 6.8 (0.4) | 1.8 (0.7 to 2.9) | <0.01 |
| HK | 1.5 (0.1) | 1.7 (0.1) | 0.2 (−0.1 to 0.5) | NS |
| LDH | 167.7 (13.3) | 146.9 (16.1) | 20 (−28 to 70) | NS |
| PFK | 71.8 (6.6) | 38.1 (2.8) | 33.6 (14 to 52) | <0.001 |