Table 3

 Histochemistry and enzymology of peripheral muscle

COPD(n = 16)Healthy subjects(n = 16)Mean difference(95% CI)p value
Values are mean (SE).
CS, citrate synthase; HADH, 3-hydroxyacyl CoA dehydrogenase; HK, hexokinase; LDH, lactate dehydrogenase; PFK, phosphofructokinase.
Relative proportion of fibre (%)
    Type I27 (3)58 (3)31 (20 to 41)<0.001
    Type IIa32 (4)29 (3)2 (−11 to 15)NS
    Type IIx22 (4)8 (2)14 (2 to 26)<0.05
    Type IIax19 (1)5 (1)3.8 (−2 to 10)NS
Enzyme activities (μmol/min/g)
    CS23.7 (0.5)27.6 (0.8)3.8 (1.4 to 6.2)<0.01
    HADH5.0 (0.2)6.8 (0.4)1.8 (0.7 to 2.9)<0.01
    HK1.5 (0.1)1.7 (0.1)0.2 (−0.1 to 0.5)NS
    LDH167.7 (13.3)146.9 (16.1)20 (−28 to 70)NS
    PFK71.8 (6.6)38.1 (2.8)33.6 (14 to 52)<0.001