Univariate analysis of early life risk factors for atopic wheeze at 10 years of age (p<0.05)
| Atopic wheeze | Non-atopic non-wheeze | OR | 95% CI | p value | |
|---|---|---|---|---|---|
| χ2 testing was used with *Fisher’s exact test where indicated by low expected cell counts. | |||||
| Factors showing statistical significance at univariate analysis (p<0.05) are shown. The strongest statistical significance was found for eczema at 1 year with a smaller but significant influence at 2 and 4 years. Similarly, food allergy had the strongest statistical significance at 1 year with a lesser but significant influence at 2 and 4 years. | |||||
| Factors showing trends for significance (p<0.2 but >0.05) were maternal rhinitis, sibling asthma, sibling rhinitis, family (parental or sibling) history of urticaria, social class I–III at birth, cat ownership at 1 year, and recurrent chest infections at 1 year. | |||||
| Factors tested but not showing trends for significance (p>0.2) were maternal eczema, maternal/paternal urticaria, maternal/paternal/parental/ family (parental or sibling) history of food allergy, sibling eczema, sibling urticaria, sibling food allergy, cat ownership at birth, 2 and 4 years, dog ownership at birth, 1, 2, and 4 years, early weaning (within first 3 ?months), exclusive breastfeeding in first 3 months, exclusive formula feeding in first 3 months, low birth weight (<2.5 kg), parental smoking throughout early life, and rhinitis at 1 and 2 years. | |||||
| Maternal asthma | 28.6% (32/112) | 16.1% (100/622) | 2.09 | 1.32 to 3.32 | 0.002 |
| Paternal asthma | 26.8% (30/112) | 12.4% (77/622) | 2.59 | 1.60 to 4.19 | <0.001 |
| Paternal eczema | 12.6% (14/111) | 6.9% (43/622) | 1.94 | 1.02 to 3.69 | 0.039 |
| Paternal rhinitis | 25.2% (28/111) | 15.0% (93/622) | 1.92 | 1.19 to 3.11 | 0.007 |
| Male sex | 63.7% (72/113) | 46.5% (305/656) | 2.02 | 1.34 to 3.05 | 0.001 |
| Eczema at 1 year | 30.5% (32/105) | 6.1% (38/622) | 6.73 | 3.97 to 11.44 | <0.001 |
| Food allergy at 1 year | 10.5% (11/105) | 4.7% (29/622) | 2.40 | 1.16 to 4.95 | 0.016 |
| Recurrent chestinfections at 2 years | 19.8% (20/101) | 11.7% (68/581) | 1.86 | 1.07 to 3.23 | 0.025 |
| Rhinitis at 4 years | 19.8% (21/106) | 3.1% (18/59) | 7.84 | 4.01 to 15.31 | <0.001 |
| Urticaria at 4 years | 2.9% (3/102) | 0.5% (3/586) | 5.72 | 1.14 to 28.71 | 0.048 |