Table 1

Clinical response to treatment

Broad spectrum antimicrobial* (n = 138)Ribavirin + corticosteroid† (n = 138)IV methylprednisolone‡ (n = 107)
*Antimicrobials included cefotaxime and clarithromycin (or levofloxacin) + oseltamivir.
†Ribavirin (oral or intravenous) + oral prednisolone or intravenous hydrocortisone.
‡Intravenous methylprednisolone up to 3 g in total.
Clinical outcome definitions: (1) afebrile (daily peak temperature ⩽37.5°C) for at least 4 consecutive days; (2) resolution of chest radiograph consolidation by >25% (comparing film of maximal consolidation and that on the 4th afebrile day); (3) oxygen independence (Sao2 ⩾95% on room air) on the 4th afebrile day.
Sustained response = 1+2+3; partial response = 1+2 or 3; no response = failure to fulfil criteria of sustained response and partial response.
Sustained response0 (0)16 (11.6%)50 (46.7%)
Partial response0 (0)9 (6.5%)45 (42.1%)
No response138 (100%)113 (81.9%)12 (11.2%)