Table 4

 Univariate analysis of early life risk factors for non-atopic wheeze in children at 10 years of age (p<0.05)

Non-atopic wheezeNon-atopic non-wheezeOR95% CIp value
χ2 testing was used with *Fisher’s exact test where indicated by low expected cell counts.
Factors showing statistical significance at univariate analysis (p<0.05) are shown. The strongest significance was found for parental smoking at 4 years with lesser statistical significance for smoking at birth, 1 and 2 years (not shown). Similarly, there was a higher significance for recurrent chest infections at 2 years than at 1 year (not shown).
Factors showing trends for significance (p<0.2 but >0.05) were maternal urticaria, paternal food allergy, cat ownership at birth, dog ownership at birth, and social class I–III at birth. Factors not showing trends for significance (p>0.2) were paternal asthma, maternal/paternal eczema, maternal/paternal rhinitis, paternal urticaria, sibling eczema, sibling rhinitis, sibling urticaria, sibling food allergy, cat ownership at 1, 2, and 4 years, dog ownership at 1, 2, and 4 years, early weaning (within first 3 months), low birth weight (<2.5 kg), rhinitis at 1 and 4 years, eczema at 2 and 4 years, food allergy at 2 and 4 years, and urticaria at 4 years.
Maternal asthma31.3% (30/96)16.1% (100/622)2.371.47 to 3.84<0.001
Maternal food allergy11.5% (11/96)3.7% (23/599)3.371.59 to 7.160.003*
Parental food allergy14.6% (14/96)4.8% (30/622)3.871.72 to 6.62<0.001
Sibling asthma41.7% (40/96)28.5% (177/622)1.801.16 to 2.790.009
Exclusively breastfed first 3 months24.4% (22/90)36.8% (215/584)0.560.33 to 0.920.022
Exclusively formula fed first 3 months50.0% (47/94)37.1% (223/601)1.701.10 to 2.620.017
Eczema at 1 year13.4% (13/97)6.1% (38/622)2.381.22 to 4.650.009
Food allergy at 1 year10.3% (10/97)4.7% (29/622)2.351.11 to 4.990.022
Rhinitis at 2 years22.1% (19/86)12.0% (70/581)2.071.17 to 3.650.011
Recurrent chest infections at 2 years30.2% (26/86)11.7% (68/581)3.271.93 to 5.53<0.001
Parental smoking at 4 years53.3% (48/90)35.0% (206/589)2.131.36 to 3.320.001