Summary of patient demographic data, BAL and pathological rejection assessments
Subject no | Age | Diagnosis | Months after transplant | BAL return (ml) | Cell count (×104/ml) | PMN(%) | AM(%) | Lymph(%) | Microbiology | Biopsy | PPI/H2 | Pepsin(ng/ml) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
CF, cystic fibrosis; PPH, primary pulmonary hypertension; OB, obliterative bronchiolitis (patient had a second lung transplant due to failure of the first); A1AT, α1-antitrypsin deficiency; LAM, lymphangiomyomatosis; VSD-EISEN, Eisenmenger’s syndrome; PMN, neutrophils; AM, alveolar macrophages; Lymph, lymphocytes; Biopsy, pathological assessment for rejection according to International Society for Heart and Lung Transplantation criteria: a = acute rejection ⩽a1 non-significant, b = airway assessment, axbx = no material for assessment; PPI/H2, prophylactic treatment with proton pump inhibitor or H2 receptor antagonist. | ||||||||||||
1 | 19 | CF | 3 | 70 | 36 | 0.2 | 99.6 | 0.2 | Negative | a2/b1 | Yes | 81 |
2 | 45 | Bronchiectasis | 6 | 95 | 67.2 | 0.2 | 96.4 | 3.4 | Negative | a0/b1 | Yes | 60 |
3 | 25 | PPH | 2.5 | 100 | 24.3 | 1.0 | 98.8 | 0.2 | Negative | a2/3b1 | Yes | 172 |
4 | 25 | OB | 3 | 100 | 34.3 | 3.4 | 96.2 | 0.2 | Negative | a1/bx | Yes | 68 |
5 | 20 | CF | 0.25 | 55 | 56.5 | 35.6 | 61.0 | 3.0 | Negative | a2/bx | No | 129 |
6 | 41 | A1AT | 2.5 | 85 | 22.8 | 7.4 | 86.4 | 5.0 | Negative | a2/b0 | No | 50 |
7 | 44 | LAM | 6 | 100 | 11 | 1.0 | 94.6 | 4.4 | Negative | a1/b1 | Yes | 34 |
8 | 44 | VSD-EISEN | 87 | 95 | 2.6 | 1.4 | 93.0 | 5.6 | Aspergillus | a0/b0 | Yes | 67 |
9 | 38 | CF | 6 | 80 | 4.7 | 4.6 | 75.8 | 18.4 | Klebsiella | a1/b1 | Yes | 107 |
10 | 62 | LAM | 12 | 90 | 39.9 | 2.0 | 94.4 | 3.6 | Negative | a0/bx | No | 1375 |
11 | 39 | Bronchiectasis | 3 | 75 | 9.6 | 8.0 | 76.0 | 15.8 | Negative | a0/b0 | Yes | 225 |
12 | 47 | A1AT | 2 | 75 | 22.6 | 5.6 | 94.2 | 0.2 | Negative | a2/b0 | Yes | 1200 |
13 | 21 | CF | 12 | 95 | 8.5 | 1.0 | 98.2 | 0.6 | Penicillium | a0/b0 | Yes | 237 |