Table 3

Inflammatory cell numbers in nasal and bronchial mucosa

Controls (n = 7)Smokers without COPD (n = 7)Smokers with COPD (n = 14)p value†
*Results are expressed as median (mean) with 25–75th percentiles.
†p value for non-parametric Kruskal-Wallis test.
‡p value for non-parametric Wilcoxon test comparing nose and bronchi.
Eosinophil
    Nose0 (0) (0–0)10 (13) (9–14)3 (3) (0–6)0.0003
    Bronchi0 (1) (0–0)7 (9) (5–10)1 (1) (0–2)0.006
    p value‡NS0.600.11
Neutrophil
    Nose0 (0) (0–0)0 (1) (0–2)46 (87) (35–165)<0.0001
    Bronchi0 (0) (0–0)0 (0) (0–1)48 (54) (0–100)0.004
    p value‡NS0.280.27
CD8 T lymphocyte
    Nose0 (0) (0–0)19 (17) (14–24)3 (9) (0–23)0.007
    Bronchi0 (0) (0–0)30 (61) (21–78)17 (15) (3–24)0.0004
    p value‡NS0.200.23
Macrophage
    Nose50 (51) (31–68)20 (20) (6–35)45 (53) (35–62)0.01
    Bronchi45 (46) (40–50)40 (39) (19–56)95 (99) (61–150)0.001
    p value‡NS0.020.01