Table 2

Characteristics of the nasal and bronchial structure in the three study groups

Controls (n = 7)Smokers without COPD (n = 7)Smokers with COPD (n = 14)p value†
*Results are expressed as median (mean) with 25–75th percentiles.
†p value for non-parametric Kruskal-Wallis test.
‡p value for non parametric Wilcoxon test comparing nose and bronchi.
Epithelial thickness (μm)
    Nose*50 (69) (42–100)48 (54) (42–69)72 (96) (58–115)0.13
    Bronchi*45 (55) (42–73)31 (30) (26–36)53 (51) (34–78)0.02
    p value‡0.130.030.02
Squamous cell metaplasia
    Nose*0 (0) (0–0)3 (2.5) (2–3)1 (1) (0–2)0.0007
    Bronchi*0 (0) (0–0)1 (1) (1–1)1.5 (1.5) (0–3)0.01
    p value‡NS0.030.008
Basement membrane thickness (μm)
    Nose*5 (4.5) (3–6)10 (9) (4–12)7 (7) (5–8)0.13
    Bronchi*6 (6) (5–7)7 (8) (5–10)7 (7) (4–9)0.74
    p value‡0.040.860.75