Association of adult asthma and lung function and maternal smoking in childhood according to atopic status (atopy defined as specific IgE to cat, grass, house dust mite and/or mould) (including 13791 subjects with information from blood tests as well as other variables)
| Non-atopics (N = 9170) | Atopics (N = 4383) | |||
|---|---|---|---|---|
| OR (95% CI)* | p value | OR (95% CI)* | p value | |
| Wheeze | 1.23 (1.08 to 1.40) | 0.002 | 1.04 (0.89 to 1.21) | 0.6 |
| >3 asthma symptoms | 1.24 (1.06 to 1.44) | 0.007 | 1.11 (0.93 to 1.31) | 0.2 |
| Current asthma | 1.11 (0.78 to 1.57) | 0.6 | 1.15 (0.92 to 1.44) | 0.2 |
| Chronic bronchitis | 1.21 (1.01 to 1.44) | 0.032 | 1.17 (0.94 to 1.47) | 0.2 |
| β coeff (95% CI)† | p value | β coeff (95% CI)† | p value | |
|---|---|---|---|---|
| *Odds ratios with 95% confidence intervals as estimated by logistic regression adjusting for sex, age, body mass index, number of siblings, current smoking, current environmental tobacco smoking, current occupation, and study centre. | ||||
| †Analysed with adjustment for interaction of sex with height, age, weight and weight squared, number of siblings, current smoking, current environmental tobacco smoking, current occupation, and study centre. | ||||
| FEV1 (ml) | −21 (−45 to 2) | 0.070 | −19 (−55 to 17) | 0.3 |
| FVC (ml) | −3 (−30 to 24) | 0.8 | 10 (−30 to 50) | 0.6 |
| FEV1/FVC ratio (%) | −0.5 (−0.8 to −0.2) | 0.003 | −0.6 (−1.1 to −0.2) | 0.008 |
| BHR (ECRHS slope) | 0.04 (−0.06 to 0.14) | 0.5 | −0.03 (−0.20 to 0.14) | 0.7 |