Table 3

 Anthropometric, spirometric, lung function, exercise and resting breathing pattern data before and after bronchodilator (BD) treatment with salbutamol in patients who increased exercise time after treatment (improvers) and those who did not (non-improvers)

Improvers(n = 12)Non-improvers(n = 6)
Values are expressed as mean (SE) and as differences between values after and before bronchodilator with 95% confidence intervals (CI).
***p<0.001, **p<0.01, *p<0.05 (before BD v after BD).
†††p<0.001, ††p<0.01, †p<0.05 (improvers v non-improvers).
M/F11/14/2
Age (years)67.6 (1.9)66.0 (2.7)
BMI (kg/m2)23.9 (1.2)25.2 (2.0)
Wmax (watt)65.9 (4.8)49.0 (6.6)
Before BD After BD Difference (95% CI) Before BD After BD Difference (95% CI)
Exercise time (s)212 (38)319 (33)107 (56 to 157)524 (95)††354 (85)−171 (−280 to −62)
FEV1 (l)1.06 (0.12)1.27 (0.13)***0.21 (0.14 to 0.27)1.30 (0.15)1.42 (0.14)**0.12 (0.04 to 0.19)
FEV1 (% pred)37.3 (4.4)44.7 (4.9)***7.4 (4.8 to 10.0)47.2 (5.2)51.5 (5.1)**4.3 (1.5 to 7.2)
FVC (l)2.66 (0.16)3.15 (0.17)***0.49 (0.27 to 0.71)2.88 (0.41)3.12 (0.37)0.24 (−0.106 to 0.58)
FVC (% pred)72.1 (3.9)85.7 (5.3)***13.7 (7.0 to 20.3)79.3 (9.7)86.2 (8.3)6.8 (−2.4 to 16.0)
FEV1/FVC (%)39.4 (2.9)40.3 (3.2)0.9 (−2.0 to 3.8)47.8 (5.4)48.0 (5.0)0.2 (−6.6 to 6.9)
FEF25% (l/s)1.08 (0.29)1.44 (0.39)**0.36 (0.13 to 0.60)1.42 (0.26)1.57 (0.22)0.15 (−0.11 to 0.42)
FEF75% (l/s)0.18 (0.02)0.27 (0.35)**0.09 (0.03 to 0.15)0.22 (0.03)0.27 (0.06)0.05 (−0.05 to 0.15)
TLC (l)8.17 (0.26)8.05 (0.35)−0.13 (−0.61 to 0.36)7.27 (0.45)6.24 (1.24)−1.03 (−4.09 to 2.03)
TLC (% pred)128.0 (3.3)125.8 (4.5)−2.2 (−9.6 to 5.3)120.0 (5.6)119.8 (5.1)2.2 (−7.5 to 11.9)
FRC (l)6.27 (0.28)5.98 (0.34)**−0.36 (−0.57 to −0.15)5.04 (0.38)†4.91 (0.29)−0.12 (−0.79 to 0.54)
FRC (% pred)185.6 (6.6)177.3 (8.0)**−11.3 (−18.4 to −4.2)155.2 (10.4)†145.6 (9.4)†−2.3 (−25.3 to 20.6)
RV (l)5.20 (0.26)4.74 (0.26)**−0.52 (−0.85 to −0.20)4.01 (0.34)†4.13 (0.22)0.12 (−0.75 to 1.00)
RV (% pred)231.7 (12.7)211.7 (11.8)−24.1 (−39.4 to −8.8)182.2 (18.7)†179.4 (7.5)6.5 (−34.7 to 47.7)
IC (l)1.91 (0.13)2.23 (0.12)***0.42 (0.23 to 0.60)2.23 (0.19)2.45 (0.30)0.22 (−0.12 to 0.57)
IC (% pred)63.7 (4.7)77.1 (4.7)***13.4 (8.2 to 18.7)76.2 (7.2)89.6 (7.3)9.7 (−6.1 to 25.4)
Vt (l)0.81 (0.04)0.91 (0.07)0.10 (−0.01 to 0.21)0.80 (0.14)0.80 (0.14)0.01 (−0.09 to 0.10)
fr (breaths/min)21.8 (2.4)23.7 (2.7)1.9 (−2.4 to 6.1)28.0 (4.5)28.4 (3.8)0.5 (−3.5 to 4.5)
Ti (s)1.21 (0.09)1.22 (0.12)0.01 (−0.16 to 0.19)1.09 (0.10)1.10 (0.07)0.01 (−0.10 to 0.11)
Te (s)2.04 (0.21)2.01 (0.28)−0.03 (−0.42 to 0.36)1.88 (0.32)1.78 (0.26)−0.10 (−0.67 to 0.47)
Vt/Ti (l/s)0.69 (0.04)0.77 (0.04)0.07 (0.01 to 0.13)0.74 (0.10)0.74 (0.11)−0.00 (−0.13 to 0.12)
Vt/Te (l/s)0.43 (0.03)0.49 (0.04)0.07 (0.02 to 0.11)0.44 (0.05)0.46 (0.05)0.02 (−0.08 to 0.11)