Multivariate regression models for predicting pulmonary function in all subjects and after excluding those aged 18 years or younger
| Outcome measure | All‡ | Non-smokers‡ | Smokers‡ | |||
|---|---|---|---|---|---|---|
| β* | p value | β* | p value | β* | p value | |
| *Beta values presented are the regression coefficients for first degree relatives with controls as the reference group with confidence intervals in parentheses. | ||||||
| †Model includes FEV1. | ||||||
| ‡Age, age2, height, height2, sex, race, and pack years in model. | ||||||
| All subjects | ||||||
| FEV1 (l) | −0.214 (−0.334 to −0.093) | 0.0005 | −0.048 (−0.194 to 0.098) | 0.5228 | −0.334 (−0.496 to −0.172) | <0.0001 |
| FVC (l) | −0.019 (−0.152 to 0.114) | 0.7749 | 0.079 (−0.076 to 0.233) | 0.3181 | −0.084 (−0.256 to 0.088) | 0.3363 |
| FEF25–75 (l/s) | −0.605 (−0.855 to −0.356) | <0.0001 | −0.357 (−0.673 to −0.041) | 0.0271 | −0.788 (−1.118 to −0.457) | <0.0001 |
| FEF25–75 (l/s)† | −0.3499 (−0.528 to −0.172) | 0.0001 | −0.294 (−0.501 to −0.088) | 0.0052 | −0.4061 (−0.647 to −0.165) | 0.0010 |
| FEF25–75/FVC (%) | −15.1 (−21.5 to −8.7) | <0.0001 | −9.5 (−17.1 to −1.9) | 0.0145 | −20.4 (−29.3 to −11.6) | <0.0001 |
| FEF25–75/FVC (%)† | −11.2 (−17.1 to −5.2) | 0.0002 | −8.7 (−15.5 to −2.0) | 0.0113 | −13.7 (−21.9 to −5.5) | 0.0011 |
| Excluding subjects aged 18 years and younger | ||||||
| FEV1 (l) | −0.197 (−0.320 to −0.073) | 0.0018 | −0.027 (−0.173 to 0.119) | 0.7142 | −0.331 (−0.493 to −0.169) | <0.0001 |
| FVC (l) | −0.002 (−0.132 to 0.129) | 0.9825 | 0.112 (−0.026 to 0.250) | 0.1128 | −0.082 (−0.254 to 0.090) | 0.3487 |
| FEF25–75 (l/s) | –0.584 (−0.844 to −0.325) | <0.0001 | −0.336 (−0.666 to −0.006) | 0.0463 | −0.782 (−1.112 to −0.452) | <0.0001 |
| FEF25–75 (l/s)† | –0.350 (−0.528 to −0.172) | 0.0001 | −0.299 (−0.503 to −0.095) | 0.0040 | −0.406 (−0.648 to −0.165) | 0.0010 |
| FEF25–75/FVC (%) | –15.1 (−21.5 to −8.7) | <0.0001 | −9.7 (−17.5 to −1.9) | 0.0148 | −20.3 (−29.2 to −11.5) | <0.0001 |
| FEF25–75/FVC (%)† | –11.2 (−17.0 to −5.5) | 0.0001 | −9.2 (−15.7 to −2.7) | 0.0056 | −13.7 (−21.9 to −5.5) | 0.0011 |