Baseline demographic and pulmonary data stratified by smoking status
| Non-smokers | Smokers | |||||
|---|---|---|---|---|---|---|
| First degree relatives (n = 132) | Controls (n = 35) | p value | First degree relatives (n = 201) | Controls (n = 48) | p value | |
| *When 22 non-smoking and two smoking first degree relatives aged 18 years or younger were removed from the analysis the means and age ranges were 39.9 (18.3–80.0) for non-smokers and 46.1 (18.1–87.0) for smokers. These values were not statistically different from controls (p = 0.884 for non-smokers, p = 0.340 for smokers). | ||||||
| †Values are mean (SD). | ||||||
| F/M | 83/49 | 18/17 | 102/99 | 29/19 | ||
| Mean (range) age* | 35.2 (7.8–80.0) | 39.9 (19.5–84.3) | 0.175 | 45.8 (15.1–87.0) | 48.6 (18.5–83.4) | 0.290 |
| Race (white/black) | 126/6 | 35/0 | 200/1 | 48/0 | ||
| Pack years smoking† | 0 | 0 | 28.1 (25.3) | 22.1 (22.1) | 0.132 | |
| FEV1 (% predicted)† | 93.90 (12.51) | 93.81 (13.24) | 0.973 | 76.74 (22.67) | 89.21 (14.42) | <0.0001 |
| FVC (% predicted)† | 99.70 (11.26) | 96.44 (13.54) | 0.149 | 88.31 (17.51) | 92.02 (9.94) | 0.053 |
| FEV1/FVC† | 77.98 (7.32) | 78.78 (6.97) | 0.560 | 68.38 (14.07) | 76.76 (8.55) | <0.0001 |
| FEF25–75 (% predicted)† | 76.02 (24.52) | 82.99 (26.33) | 0.143 | 54.70 (29.96) | 77.90 (35.57) | <0.0001 |
| FEF25–75/FVC† | 72.05 (24.12) | 77.15 (24.01) | 0.267 | 51.58 (27.50) | 70.34 (26.91) | <0.0001 |