Table 1

Estimates of the worldwide numbers of carriers (Pi MS and PiMZ) and subjects at high risk for developing lung/liver disease associated with AAT deficiency (excluding Central and South America)

Geographical regionCarriersIndividuals with AAT deficiency
Pi MSPi MZPi SZPi ZZ
Simplified from de Serres.13
Northern Europe106435010274522115011578
Central Europe1049989639330488566117514
Southern Europe20148269394667226278027515
Western Europe533781814956807198310146
North America18469434715590125770853173
Australia/New Zealand1816658639174282315476
Middle East/North Africa16690909032323226610657
Africa173343071404344750966412
Central Asia649996245069794081520504
South-east Asia406347216052983789810706
Far East Asia191127660746035531771
Total 88814533 27225242 929014 175268