Table 1

 Biochemical markers of systemic inflammation, clinical characteristics, and annual change in bone mineral content in cystic fibrosis patients infected with Pseudomonas aeruginosa and Burkholderia cepacia

P aeruginosaB cepaciap value
IL-6 = interleukin 6; CRP = C reactive protein; FEV1 = forced expiratory volume in 1 second; BMI = body mass index; BMC = bone mineral content.
*Mann-Whitney U test.
†Unpaired Student’s t test.
Median (IQR) IL-6 (pg/ml)4.7 (1.9–9.0)9.5 (5.2–19.5)0.01*
Median (IQR) CRP (mg/l)7.5 (5.0–26.5)20.0 (7.5–34.0)0.11*
Median (IQR) intravenous antibiotic use (days)23 (0–46)44 (13–72)0.12*
Median (IQR) prednisolone use (mg/day)0.6 (0–2.2)1.2 (0–4.7)0.47*
Mean (SD) physical activity score (3–15)7.8 (1.1)7.8 (1.3)0.80†
Mean (SD) baseline FEV1 (% predicted)61.9 (24)54.9 (20.4)0.23†
Mean (SD) annual change in FEV1 (% predicted)−2.0 (8.4)−2.1 (8.0)0.95†
Mean (SD) annual change in BMI (kg/m2)0.25 (1.1)0.08 (0.89)0.52†
Mean (SD) annual change in BMC (%)−0.06 (2.61)−2.78 (2.88)<0.001†