Biochemical markers of systemic inflammation, clinical characteristics, and annual change in bone mineral content in cystic fibrosis patients infected with Pseudomonas aeruginosa and Burkholderia cepacia
| P aeruginosa | B cepacia | p value | |
|---|---|---|---|
| IL-6 = interleukin 6; CRP = C reactive protein; FEV1 = forced expiratory volume in 1 second; BMI = body mass index; BMC = bone mineral content. | |||
| *Mann-Whitney U test. | |||
| †Unpaired Student’s t test. | |||
| Median (IQR) IL-6 (pg/ml) | 4.7 (1.9–9.0) | 9.5 (5.2–19.5) | 0.01* |
| Median (IQR) CRP (mg/l) | 7.5 (5.0–26.5) | 20.0 (7.5–34.0) | 0.11* |
| Median (IQR) intravenous antibiotic use (days) | 23 (0–46) | 44 (13–72) | 0.12* |
| Median (IQR) prednisolone use (mg/day) | 0.6 (0–2.2) | 1.2 (0–4.7) | 0.47* |
| Mean (SD) physical activity score (3–15) | 7.8 (1.1) | 7.8 (1.3) | 0.80† |
| Mean (SD) baseline FEV1 (% predicted) | 61.9 (24) | 54.9 (20.4) | 0.23† |
| Mean (SD) annual change in FEV1 (% predicted) | −2.0 (8.4) | −2.1 (8.0) | 0.95† |
| Mean (SD) annual change in BMI (kg/m2) | 0.25 (1.1) | 0.08 (0.89) | 0.52† |
| Mean (SD) annual change in BMC (%) | −0.06 (2.61) | −2.78 (2.88) | <0.001† |