Clinical features of CF patients according to NOS1 genotype
| Number of alleles with more than 27 repeats | |||
|---|---|---|---|
| 0 | 1 | 2 | |
| CFTR = cystic fibrosis transmembrane regulator; BMI = body mass index; n = number of patients in each category; S, M and ND = severe, mild and not determined CFTR genotypes, respectively. | |||
| When appropriate, values are expressed as mean (SD). No statistical differences were found (using χ2 analysis for categories and ANOVA for continuous variables) except for decline in lung function (p = 0.025). | |||
| *Colonisation with P aeruginosa/B cepacia. | |||
| Patients (n) | 16 | 24 | 19 |
| Age (years) | 31.4 (8.3) | 28.9 (8.3) | 28.8 (7.5) |
| M:F | 11:5 | 11:13 | 12:7 |
| CFTR genotype (S/M/ND) | 13/1/2 | 18/1/5 | 12/1/6 |
| Diabetes (n) | 4 | 3 | 1 |
| Pancreatic insufficiency (n) | 15 | 20 | 17 |
| BMI (kg/m2) | 19.0 (2.2) | 18.9 (2.3) | 18.8 (1.7) |
| Airway bacterial colonisation* (n) | 12/1 | 17/2 | 18/1 |
| Annual FEV1 loss (% predicted) | |||
| Mean | 3.3 | 3.2 | 0.8 |
| 95% CI | 1.1 to 5.4 | 2.4 to 4.0 | −0.5 to 2.1 |