Comparison of mean bone mineral density (in g/cm2) adjusted for age, sex, and height in controls and subjects with CF and difference in adjusted mean values (with 95% CI) in the three age groups (children, adolescents, and adults)
| Children | Adolescents | Adults | |||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean (SE) | p value | N | Mean (SE) | p value | N | Mean (SE) | p value | |
| *Difference in means calculated by (control – CF). | |||||||||
| Total body | |||||||||
| Control | 32 | 0.85 (0.01) | 0.65 | 75 | 1.05 (0.01) | 0.03 | 41 | 1.17 (0.01) | 0.002 |
| CF | 40 | 0.86 (0.01) | 55 | 1.01 (0.01) | 57 | 1.11 (0.01) | |||
| Difference* | −0.01 (−0.03 to 0.02) | 0.04 (0.01 to 0.07) | 0.05 (0.02 to 0.09) | ||||||
| Lumbar spine | |||||||||
| Control | 32 | 0.67 (0.02) | 0.31 | 75 | 0.97 (0.01) | 0.14 | 42 | 1.18 (0.02) | 0.003 |
| CF | 40 | 0.69 (0.01) | 55 | 0.93 (0.02) | 58 | 1.10 (0.02) | |||
| Difference* | −0.02 (−0.06 to 0.02) | 0.04 (−0.01 to 0.08) | 0.08 (0.03 to 0.14) | ||||||
| Femoral neck | |||||||||
| Control | 32 | 0.72 (0.02) | 0.79 | 75 | 0.99 (0.02) | 0.07 | 42 | 1.03 (0.02) | 0.002 |
| CF | 37 | 0.71 (0.02) | 47 | 0.94 (0.02) | 58 | 0.94 (0.02) | |||
| Difference* | 0.01 (−0.05 to 0.07) | 0.05 (0.00 to 0.11) | 0.09 (0.03 to 0.15) | ||||||
| Ultra distal radius | |||||||||
| Control | 32 | 0.25 (0.01) | 0.86 | 74 | 0.33 (0.01) | 0.12 | 41 | 0.38 (0.01) | 0.009 |
| CF | 36 | 0.24 (0.01) | 46 | 0.30 (0.01) | 57 | 0.35 (0.01) | |||
| Difference* | 0.00 (−0.02 to 0.02) | 0.02 (0.00 to 0.05) | 0.03 (0.01 to 0.05) | ||||||
| Cortical radius | |||||||||
| Control | 32 | 0.44 (0.01) | 0.75 | 74 | 0.61 (0.01) | 0.01 | 41 | 0.72 (0.01) | 0.07 |
| CF | 36 | 0.44 (0.01) | 46 | 0.58 (0.01) | 57 | 0.70 (0.01) | |||
| Difference* | 0.00 (−0.02 to 0.02) | 0.03 (0.01 to 0.06) | 0.02 (0.00 to 0.04) | ||||||
| Principal component | |||||||||
| Control | 32 | −2.49 (0.13) | 0.82 | 74 | 0.37 (0.13) | 0.07 | 41 | 1.91 (0.17) | 0.001 |
| CF | 36 | −2.45 (0.13) | 46 | −0.08 (0.18) | 57 | 1.16 (0.14) | |||
| Difference* | −0.04 (−0.41 to 0.32) | 0.45 (0.02 to 0.88) | 0.74 (0.31 to 1.18) | ||||||