Table 1

Effect of allergen challenge on clearance of eosinophils from airway tissue

Time (min)Effect of challenge†p value‡
†Effect of challenge expressed as the quotient of ovalbumin (OVA) v saline treatment (95% CI).
‡The significance of difference between treatments and time points overall.
*p<0.05, **p<0.01, ***p<0.001.
Intraepithelial eosinophils21.0 (0.7 to 1.4)
100.6 (0.5 to 0.9) **
300.3 (0.1 to 0.5) **
600.2 (0.1 to 0.5) **<0.0001
Subepithelial eosinophils20.9 (0.4 to 1.9)
100.9 (0.4 to 2.0)
300.4 (0.2 to 0.7) **
600.2 (0.1 to 0.4) ***0.0013
Total tissue eosinophils20.9 (0.6 to 1.4)
100.7 (0.5 to 0.9) *
300.3 (0.2 to 0.5) **
600.2 (0.1 to 0.4) ***<0.0001
Lavage content of eosinophils20.8 (0.2 to 3.6)
107.0 (1.1 to 46) *
3012 (1.5 to 108)*
6032 (3.3 to 314)**0.0004
Eosinophil cytolysis20.9 (0.5 to 1.5)
101.0 (0.5 to 3.6)
303.6 (1.6 to 8.0)**
605.9 (2.8 to 12)**<0.0001
Neutrophils24.6 (1.4 to 15)*
1022 (5.6 to 86)**
3020 (3.8 to 107)**
6036 (8.3 to 158)***0.0008