Relationship of TIMP-3 haplotypes with lung function, BAL cell profile, and outcome in subjects with pigeon breeders’ disease (PBD)
| TIMP-3 haplotype | |||
|---|---|---|---|
| *A*T | *G*C | p value | |
| FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; Pao2 = arterial oxygen tension; BAL = bronchoalveolar lavage. | |||
| Lung function and BAL cell profile data are expressed as mean (SD). The effect of haplotype on the data was determined using stepwise regression analysis with age and smoking as covariates. | |||
| Age | 44.1 (13.3) | 43.5 (14.5) | 0.77 |
| FEV1 (% predicted) | 59.5 (20.0) | 61.3 (19.7) | 0.49 |
| FVC (% predicted) | 56.4 (20.8) | 56.8 (19.4) | 0.75 |
| Pao2 (kPa) | 7.1 (1.4) | 7.0 (1.3) | 0.70 |
| BAL lymphocytes (%) | 63.9 (20.3) | 55.0 (21.4) | 0.029 |
| BAL macrophages (%) | 33.6 (20.1) | 43.0 (20.3) | 0.016 |
| BAL neutrophils (%) | 1.4 (2.5) | 1.2 (3.4) | 0.49 |
| BAL eosinophils (%) | 0.8 (1.0) | 0.7 (1.2) | 0.65 |
| % of subjects with haplotype having a poorer outcome | 41.1 | 41.0 | 0.83 |