Table 3

Effect of salmeterol on dyspnoea and operational lung volumes during treadmill exercise

PlaceboSalmeterolMean difference (95% CI)p value
Values are mean (SD) and mean treatment differences with 95% CI except for resting Borg scores where values are median (25th, 75th interquartile range).
Borg = modified Borg dyspnoea scale; Δ = change from rest to end isotime; IC = inspiratory capacity; DH = dynamic hyperinflation; EELV = end expiratory lung volume; EILV = end inspiratory lung volume; TLC = total lung capacity; IRV = inspiratory reserve volume; ISO = isotime
*Significant period × treatment interaction.
Rest Borg0.0 (0.0, 0.5)0.0 (0.0, 0.5)0.03 (−0.17 to 0.24)0.75
ISO Borg4.62 (1.09)3.78 (1.14)−0.84 (−1.54 to −0.14) 0.02
ΔBorg4.34 (1.22)3.47 (1.07)−0.87 (−1.55 to −0.20) 0.01
Rest IC (l)1.32 (0.43)1.48 (0.52)0.16 (0.02 to 0.32) 0.03*
ISO IC (l)0.98 (0.44)1.27 (0.51)0.29 (0.11 to 0.44) 0.002
DH (ΔIC) (l)0.33 (0.20)0.22 (0.15)−0.11 (−0.18 to −0.04) 0.002
Rest EELV/TLC (%)80.0 (4.0)76.6 (7.7)−3.4 (−6.3 to −0.6) 0.02
ISO EELV/TLC (%)85.3 (5.1)80.3 (6.9)−5.0 (−8.0 to −2.2) 0.002
Δ EELV/TLC (%)5.3 (3.3)3.7 (2.6)−1.6 (−2.7 to −0.7) 0.003
Rest EILV/TLC (%)90.2 (4.2)87.1 (6.0)−3.1 (−5.6 to −0.6) 0.02
ISO EILV/TLC (%)98.2 (5.7)93.5 (5.3)−4.7 (−7.6 to −1.8) 0.004
Δ EILV/TLC (%)8.0 (4.3)6.4 (4.5)−1.6 (−3.3 to 0.1)0.07
ISO Sao2 (%)87.0 (6.7)87.8 (6.4)0.8 (−0.4 to 1.9)0.18
Endurance time (s)333 (151)347 (180)14 (−23.9 to 52.0)0.44