Multivariate analysis of early life risk factors for atopic and non-atopic wheeze at 10 years (p<0.2)
| Risk factor | OR | 95% CI | p value | |
|---|---|---|---|---|
| The regression models used the outcomes of each respective wheeze status compared with having non-atopic non-wheeze. Only factors which had a significant effect at the final step of each regression model are shown. | ||||
| Factors entered into the regression model for non-atopic wheeze at 10 years were maternal asthma, maternal urticaria, parental food allergy, sibling asthma, cat ownership at birth, dog ownership at birth, social class I–III at birth, exclusive breastfeeding for first 3 months, parental smoking at 4 years, recurrent chest infections at 1 year, recurrent chest infections at 2 years, eczema at 1 year, food allergy at 1 year, and rhinitis at 2 years. | ||||
| Factors entered into the regression model for atopic wheeze were maternal asthma., paternal asthma, paternal eczema, maternal rhinitis, paternal rhinitis, sibling asthma, sibling rhinitis, family history (parent or sibling) of urticaria, cat ownership at 1 year, social class I–III at birth, recurrent chest infections at 1 year, chest infections at 2 years, eczema at 1, 2, and 4 years, food allergy at 1 year, rhinitis at 4 years, urticaria at 4 years, and male sex. | ||||
| Non-atopic wheeze | Maternal asthma | 4.08 | 1.85 to 9.00 | <0.001 |
| Recurrent chest infections at 2 years | 3.99 | 1.78 to 8.92 | 0.001 | |
| Atopic wheeze | Sibling asthma | 2.10 | 1.04 to 4.23 | 0.039 |
| Eczema at 1 year | 2.80 | 1.01 to 7.80 | 0.048 | |
| Rhinitis at 4 years | 4.74 | 1.61 to 13.47 | 0.005 | |
| Male sex | 2.73 | 1.36 to 5.48 | 0.005 | |