Changes in markers of bronchial inflammation between days 1 and 10 and day 1 and the stable clinical state, comparing those eradicating bacteria with those patients with persistent pathogens
| Change between days 1 and 10 | Change between day 1 and the stable state | |||
|---|---|---|---|---|
| Eradicated | Persistent | Eradicated | Persistent | |
| MPO=myeloperoxidase; NE=neutrophil elastase; LTB4=leuoktriene B4; IL-8-interleukin 8; SLPI=secretory leukoprotease inhibitor. | ||||
| *p<0.05, **p<0.01, differences between groups (Mann-Whitney U-test). | ||||
| ΔMPO (units/ml) | −0.67 (−1.88 to −0.25) | −0.15* (−1.07 to 0.28) | −0.79 (−1.52 to −0.15) | −0.25 (−1.26 to 0.25) |
| ΔNE (nM) | −2.79 (−13.46 to 0.00) | −10.90 (−25.74 to 0.00) | −1.33 (−11.56 to 0.00 | −3.28 (−93.39 to −0.46) |
| ΔLTB4 (nM) | −5.81 (−24.64 to −2.37) | −3.49* (−9.41 to 0.37) | −6.49 (−14.22 to −2.82) | −0.064** (−3.35 to 16.18) |
| ΔIL–8 (nM) | −3.19 (−8.48 to −0.03) | −0.69 (−5.01 to 2.86) | −0.25 (−4.41 to 0.92) | −2.70 (−9.46 to 3.77) |
| ΔSLPI (μM) | 0.17 (−0.64 to 0.65) | 0.11 (−1.84 to 1.60) | 4.09 (1.21 to 5.15) | 1.09* (−0.31 to 3.16) |
| ΔAlbumin ratio (%) | −0.61 (−1.94 to −0.11) | −1.78 (−3.14 to −0.23) | −0.70 (−1.73 to −0.01 | −1.82 (−3.12 to −0.48) |