Table 1

Changes in markers of bronchial inflammation and bacterial load from day 1 to day 10

Eradicated (n=23)Persistent (n=17)
Day 1Day 10Day 1Day 10
Results are presented as median (interquartile range).
MPO=myeloperoxidase; NE=neutrophil elastase; LTB4=leuoktriene B4; IL-8-interleukin 8; SLPI=secretory leukoprotease inhibitor.
*p⩽0.006, **p<0.001 compared with presentation (Wilcoxon signed rank test).
†p<0.05, ††p<0.001 compared with “eradicated” group (Mann-Whitney U test).
MPO (units/ml)0.95 (0.44–2.190)0.22** (0.15–0.41)1.12 (0.54–1.85)0.65† (0.42–1.41)
NE (nM)6.91 (0.84–15.73)0.00* (0.00–8.80)10.90 (1.13–31.59)0.00* (0.00–18.23)
LTB4 (nM)11.0 (4.70–25.76)1.59** (0.46–5.48)8.84 (5.57–20.79)7.17†† (3.46–21.00)
IL-8 (nM)6.69 (3.68–13.40)3.12* (1.08–4.92)6.01 (2.71–13.14)5.00 (2.25–11.18)
SLPI (μM)1.03 (0.32–2.65)1.42 (0.62–3.12)1.24 (0.52–2.96)1.73 (0.90–2.81)
Albumin ratio (%)1.12 (0.65–3.09)0.47** (0.24–0.75)2.77 (0.86–4.39)0.53** (0.37–0.93)
Pathogen load (cfu/ml)1.2×108 (3×107−1.1×109)6.3×108 (8.7×107−1.7 × 109)1.7×108 (1.6×107−7.7×108