Analysis to determine which parameters are associated with pancreatic insufficiency
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| All quantitative variables were dichotomised according to the median or to a cut off point of 50% of the predicted value (% pred) for FEV1. Fisher’s exact test was used for univariate analysis and a logistic regression was performed for multivariate analysis. | ||||
| OR, odds ratio; CI, confidence interval; BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; Pao2, Paco2, arterial oxygen and carbon dioxide tensions. | ||||
| Severe genotype | 16.0 (3.2 to 80.9) | <0.001 | 28.2 (4.5 to 178.1) | <0.001 |
| BMI <20 | 2.9 (0.9 to 9.6) | 0.1 | 8.8 (1.3 to 58.3) | 0.03 |
| P aeruginosa colonisation | 2.8 (0.9 to 9.0) | 0.08 | ||
| FEV1 <50% pred | 3.3 (0.8 to 13.4) | 0.09 | ||
| FVC <70% pred | 2.5 (0.8 to 8.3) | 0.16 | ||
| Pao2 <10.4 kPa | 2.7 (0.8 to 9.0) | 0.16 | ||
| Paco2 ⩾5.5 kPa | 0.8 (0.3 to 2.4) | 0.78 | ||
| Basal nasal PD ⩽−47 mV | 1.6 (0.5 to 4.9) | 0.42 | ||
| Δamil ⩾29 mV | 1.2 (0.4 to 3.5) | 0.79 | ||
| ΔCl−/amil >−5 mV | 5.0 (1.2 to 20.3) | 0.01 | 8.6 (1.3 to 58.5) | 0.03 |
| Δiso/Cl− >2 mV | 5.8 (1.1 to 29.5) | 0.02 | 11.2 (1.3 to 93.9) | 0.03 |