Pulmonary function in both groups at baseline and 3, 6, 9 and 12 months†
| Baseline | 3 months | 6 months | 9 months | 12 months | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Surgical | Control | Surgical | Control | Surgical | Control | Surgical | Control | Surgical | Control |
| For definition of abbreviations see footnote to table 1. | ||||||||||
| *Significant difference between groups (p<0.05). | ||||||||||
| † Follow up measures are least square means adjusted for baseline. | ||||||||||
| TLC (% pred) | 142 (4) | 151 (5) | 129 (4)* | 151 (4) | 133 (4)* | 150 (4) | 135 (4)* | 148 (4) | 134 (4)* | 149 (4) |
| FRC (% pred) | 193 (8) | 205 (9) | 162 (11)* | 207 (10) | 167 (11)* | 208 (10) | 170 (11)* | 212 (10) | 171 (11)* | 212 (10) |
| RV (% pred) | 228 (10) | 253 (13) | 184 (9)* | 235 (8) | 191 (8)* | 236 (8) | 195 (9)* | 241 (8) | 192 (9)* | 239 (8) |
| FVC (l) | 2.3 (0.2) | 2.5 (0.2) | 2.9 (0.1)* | 2.4 (0.1) | 3.0 (0.1)* | 2.3 (0.1) | 2.9 (0.1)* | 2.4 (0.1) | 2.9 (0.1)* | 2.2 (0.1) |
| FVC (% pred) | 71 (5) | 73 (3) | 88 (3)* | 77 (3) | 89 (3)* | 72 (3) | 89 (3)* | 75 (3) | 88 (3)* | 70 (3) |
| FEV1 (l) | 0.8 (0.1) | 0.7 (0.0) | 1.0 (0.1)* | 0.7 (0.1) | 1.1 (0.1)* | 0.7 (0.1) | 1.0 (0.1)* | 0.7 (0.2) | 1.0 (0.1)* | 0.7 (0.1) |
| FEV1 (% pred) | 33 (3) | 32 (2) | 45 (2)* | 33 (2) | 45 (2)* | 31 (2) | 44 (2)* | 32 (2) | 41 (2)* | 30 (2) |
| FEV1/FVC (%) | 33 (2) | 32 (2) | 37 (1)* | 31 (1) | 36 (1)* | 30 (1) | 35 (1)* | 30 (1) | 33 (1)* | 30 (1) |
| V50 (l/s) | 0.31 (0.03) | 0.30 (0.02) | 0.42 (0.03)* | 0.29 (0.02) | 0.44 (0.03)* | 0.26 (0.02) | 0.37 (0.03)* | 0.25 (0.02) | 0.35 (0.03)* | 0.24 (0.02) |
| V25 (l/s) | 0.18 (0.02) | 0.15 (0.01) | 0.19 (0.01) | 0.17 (0.01) | 0.20 (0.01)* | 0.15 (0.01) | 0.17 (0.01) | 0.14 (0.01) | 0.17 (0.01)* | 0.14 (0.01) |
| VA (% pred) | 74 (3) | 73 (3) | 78 (2) | 75 (2) | 77 (2) | 78 (2) | 78 (2) | 75 (2) | 77 (2) | 74 (2) |
| Tlco (% pred) | 35 (2) | 38 (2) | 34 (2) | 36 (2) | 36 (2) | 32 (2) | 37 (2) | 33 (2) | 37 (2) | 33 (2) |
| MIPRV (cm H2O) | −57 (5) | −48 (5) | −62 (4)* | −47 (4) | −66 (4)* | −53 (4) | −64 (4) | −53 (4) | −63 (4) | −53 (4) |
| MEPTLC (cm H2O) | 82 (7) | 88 (8) | 92 (9) | 75 (9) | 91 (9)* | 66 (9) | 84 (9) | 79 (9) | 102 (9) | 89 (9) |
| 6 min walk (m) | 387 (15) | 372 (17) | 373 (13) | 356 (12) | 403 (13)* | 346 (12) | 400 (13)* | 340 (12) | 389 (13)* | 323 (12) |