Table 3

Correlation between pretreatment levels of anti-GM-CSF antibody, surfactant protein (SP)-A, SP-B, serum lactate dehydrogenase (LDH), and other indicators of disease severity

ParameterAnti-GM-CSF Ab (μg/ml)p valueSP-A (μg/ml)*p valueSP-B (μg/ml)†p valueLDH (%ULN)p value
Po2=arterial oxygen tension; [A–a]Do2=alveolar-arterial oxygen gradient; VC=vital capacity; Tlco=carbon monoxide transfer factor.
*Normal range for serum level of SP-A is <0.25 μg/ml. Values were not normally distributed so analysis was performed following log10 transformation of data.
†Normal range for serum level of SP-B is <2.6 μg/ml. Values were not normally distributed so analysis was performed following log10 transformation of data.
Arterial Po2 (mm Hg) (n=11)–0.123NS–0.7040.01–0.247NS–0.175NS
[A – a]Do2 (mm Hg) (n=11)0.123NS0.7150.0090.088NS0.025NS
VC (% predicted) (n=12)–0.022NS–0.6460.020.210NS–0.461NS
Tlco (% predicted) (n=12)0.017NS–0.8290.00090.179NS–0.482NS
LDH (%ULN) (n=12)0.237NS0.4620.10.056NS
SP-B (μg/ml) (n=12)†0.123NS–0.321NS
SP-A (μg/ml) (n=12)*0.189NS